We should note that MAF kills specifically Treg59, which is harnessed for stimulation of the immune response by low-dose treatment with cyclophosphamide67,68. The inability of TMZ to kill resting T cells might
Regardless of an endogenous expression or a protein acquisition, MHCII on T cells has mainly been associated with induction of down regulatory signals in the responding T cell [11,23,24,25]. It has also been associated with active rather than resting regulatory T cells (Tregs) [26]. ...