CD40在三特异性抗体(trispecific antibody)药物中同样发挥重要作用。三特异性抗体是一类新兴的抗体药物,可同时识别和结合三种不同抗原,进一步拓展了抗体药物的应用范围和治疗策略。将CD40作为三抗药物的一个靶点,可发挥以下作用: 1 增强T细胞募集和激活:一些三抗药物同时靶向CD40、肿瘤相关抗原和T细胞表面受体(如CD3)。...
These bispecific reagents demonstrate a superior safety profile compared to their parental CD40 monospecific antibody while triggering potent antitumor activity. We suggest such cell-selective bispecific agonistic antibodies as a drug platform to bypass the dose-limiting toxicities of anti-CD40, and of ...
别名 Anti-PD-L1/CD40 bispecific antibody (Harbour BioMed)、HBM 9027、HBM9027 靶点 CD40 x PDL1 作用机制 CD40抑制剂(肿瘤坏死因子受体超家族成员5抑制剂)、PDL1抑制剂(程序性死亡配体1抑制剂) 治疗领域 肿瘤 在研适应症 晚期恶性实体瘤实体瘤 非在研适应症- 原研机构 和铂医药(上海)有限责任公司 在研机...
次优活化可以通过滴定添加至pbmc池的抗cd3抗体的浓度、测量t细胞增殖和选择抗cd3抗体浓度来测定,所述抗cd3抗体的浓度导致低t细胞增殖但允许进一步增强t细胞增殖。该浓度是pbmc供体依赖性的,并且在进行测定法之前测定每个供体。 在一个实施方案中,通过活化具有所述次优浓度的抗cd3抗体的pbmc中的t细胞、使pbmc与多特异性...
Extremely potent, rapid and costimulation-independent cytotoxic T-cell response against lymphoma cells catalyzed by a single-chain bispecific antibody. A recent study reported on an anti-CD19/anti-CD3 single-chain bispecific antibody (bscCD19xCD3) exhibiting high activity against human B lymphoma ...
An isolated monoclonal antibody that specifically binds human CD40. A nucleic acid molecule encoding the antibody, an expression vector, a host cell and a method for expressing the antibody are also provided. The present invention further provides an immunoconjugate, a bispecific molecule, a chimeric...
The present invention further provides an immunoconjugate, a bispecific molecule, an oncolytic virus, and a pharmaceutical composition comprising the antibody or the antigen-binding portion thereof, as well as a diagnostic and treatment method using an anti-CD40 antibody or the antigen-binding portion...
In a specific embodiment, the antibody to a CD40 polypeptide, peptide or other derivative, or analog thereof comprising all or a portion of SEQ ID NO:1 or SEQ ID NO:6 is a bispecific antibody (see generally, e.g. Fanger and Drakeman, 1995, Drug News and Perspectives 8: 133-137). ...
A nucleic acid molecule encoding the antibody or antigen-binding portion thereof, an expression vector, a host cell and a method for expressing the antibody or antigen-binding portion thereof are also provided. The present disclosure further provides an immunoconjugate, a bispecific molecule, a ...
and Lachmann, P.J., “Bispecific Antibody: A Tool for Diagnosis and Treatment of Disease,” Clinical and Experimental Immunology, 79(3):315-321, Blackwell Scientific Publications, United Kingdom (1990). Spiro, R.G., “Protein Glycosylation: Nature, Distribution, Enzymatic Formation, and ...