Topp, MS, Zugmaier, G, Goekbuget, N (2010) CD19/CD3 bispecific antibody blinatumomab (MT-103) is highly effective in treatment of patients with minimal residual disease from chemotherapy-resistant B-precursor a
本研究中的 CN201 是一种新型 CD3 x CD19 双特异性抗体,其作用机制与贝林妥欧单抗相似。该抗体一端靶向 CD3,与体内 T 细胞连接,另一端靶向 CD19,即急性淋巴细胞白血病细胞的靶抗原。这种双特异性抗体的作用类似「双面胶」,使...
英文名称：Humanized anti-human CD3/CD19 bispecific antibody 适用范围 AMMS TM CD3/CD19 BsAb是一种双特异性T细胞连接蛋白，这种蛋白可以连接T细胞和癌细胞，令T细胞可以 选择性地接近癌细胞而达到特异性杀伤的治疗效果。AMMS TM CD3/CD19 BiMab不仅是简单地把T细胞与肿瘤 细胞相结合，还通过与T细胞表面CD3受体相...
参考文献: Ying Wang, Qingsong Yin, Jinhai Ren, et al. Phase I study of CN201, a novel CD3xCD19 IgG4 bispecific antibody, in adult patients with relapsed or refractory B-cell acute lymphoblastic leukemia. 2024 ...
Anti-hCD19-CD3 is a bispecific antibody that recognizes two human cell markers: hCD19, which is expressed on the surface of (malignant) B cells, and hCD3 which is part of the T cell receptor. This antibody features blinatumomab’s single-chain variable fragments (scFv) joined by a glycin...
Recombinant Anti-CA19-9 x Anti-CD3 Bispecific Antibody (Triple Body) is designed to be expressed as two polypeptide chains respectively. The Fd fragment and LC from an anti-CA19-9 antibody are both extended with the scFv fragment from an anti-CD3 antibody. This BsAb can retarget T cells ...
Jurkat CD3-BsAb Reporter Cell Line与贴壁细胞共培养,然后使用Anti-CD3-CD19 Bispecific Antibody(Blinatumomab)、Anti-CD3 epsilon hIgG1 Antibody [OKT-3 (muromonab)]抗体验证结果 Jurkat CD3-BsAb Reporter Cell Line与悬浮细胞共培养,然后使用Anti-CD3-CD19 Bispecific Antibody(Blinatumomab)、Anti-CD3 epsilon ...
Jurkat CD3-BsAb Reporter Cell Line与悬浮细胞共培养,然后使用Anti-CD3-CD19 Bispecific Antibody(Blinatumomab)、Anti-CD3 epsilon hIgG1 Antibody [OKT-3 (muromonab)]抗体验证结果 02、GM-C32931 H_CD3 CHO-K1 Cell Line使用Anti-CD3 hIgG1 Antibody(CH2527)抗体稳定性验证结果 03、GM-C30877 H_CD3 HEK-...
与悬浮细胞共培养,然后使用Anti-CD3-CD19 Bispecific Antibody(Blinatumomab)、Anti-CD3 epsilon hIgG1 Antibody [OKT-3 (muromonab)]抗体验证结果 GM-C32931:H_CD3 CHO-K1 Cell Line 使用Anti-CD3 hIgG1 Antibody(CH2527)抗体 稳定性验证结果 GM-C30877:H_CD3 HEK-293 Cell Line ...
CD19 is expressed on most B cells with the exception of stem cells and plasma cells, and is frequently expressed on most human B cell lymphoma and leukemias except for multiple myeloma. One representative of the BiTE class is the CD19-/CD3-bispecific antibody MT103 (bscCD19 ×CD3), ...