随着精细针吸取淋巴结或组织活检的日益普及，结合最近开发的细胞因子非依赖的识别病原体特异性记忆CD4+T细胞的方法，有助于更多种类的CD4+记忆亚群的检测。激活诱导标志物（activation-induced marker, AIM）试验利用OX40和CD25在抗原刺激后的上调现象，特别适用于在不知道确切CD4+ T细胞表位的情况下检测记忆CD4+ T细胞。
CD4_markers_step3=list(T_check=c("CD3D","CD3E","CD4",'CD8A',"PTPRC"),Naive=c("CCR7"),Tcm=c("ANXA1","TCF7"),`Temra/Teff`=c("GNLY"),Treg=c("FOXP3","CTLA4"),Th1=c("IFNG","CXCL13"),`Th1/Th1`=c("GZMK","BHLHE40"),Th17=c("IL23R"),Tfh=c("CXCR5"),Trm=c("CXCR6...
随着精细针吸取淋巴结或组织活检的日益普及,结合最近开发的细胞因子非依赖的识别病原体特异性记忆CD4+T细胞的方法,有助于更多种类的CD4+记忆亚群的检测。激活诱导标志物(activation-induced marker, AIM)试验利用OX40和CD25在抗原刺激后的上调现象,特别适用于在不知道确...
随着精细针吸取淋巴结或组织活检的日益普及,结合最近开发的细胞因子非依赖的识别病原体特异性记忆CD4+T细胞的方法,有助于更多种类的CD4+记忆亚群的检测。激活诱导标志物(activation-induced marker, AIM)试验利用OX40和CD25在抗原刺激后的上调现象,特别适用于在不知道确切CD4+ T细胞表位的情况下检测记忆CD4+ T细胞。此...
CXCL13:滤泡辅助性T细胞(Tfh) 的标志物,促进B细胞活化和生发中心形成。 CCL3/CCL4/CCL20:趋化因子,常见于活化的T细胞(如Th1、Th17)或 调节性T细胞(Treg),参与招募免疫细胞。 NK细胞 GNLY 和 XCL1:NK细胞 的典型效应分子,参与抗病毒和抗肿瘤反应。
CD4, also known as L3T4, T4, and W3/25, is an approximately 55 kDa type I transmembrane glycoprotein that is expressed predominantly on thymocytes and a subset of mature T lymphocytes. It is a standard phenotype marker for the identification of T cell populations (1). Mature human CD4 cons...
CD4, also known as L3T4, T4, and W3/25, is an approximately 55 kDa type I transmembrane glycoprotein that is expressed predominantly on thymocytes and a subset of mature T lymphocytes. It is a standard phenotype marker for the identification of T cell populations. Mature human CD4 consists ...
Tfh cells can also be further differentiated into more specific cells. Th9 — Previously thought to be a subset of Th2 cells, Th9 is considered to be a separate T helper subset that may play a role in some asthma endotypes. classified as its own specific differentiated cell lineage. ...
Tfh cells Tfh cells are a subset of CD4+T cells first identified in human tonsil [96,97], which help the formation of germinal centres (GCs), and promote the generation of high-affinity antibodies and the development of memory B cells [98,99,100]. Tfh cells play an important role in ...
CX3CR1+ T cells did not express CCR4 (Th2 or Treg marker), CCR6 (Th17 marker), or CXCR5 (Tfh marker), indicating an independent T cell subset (Fig. 3a). We also confirmed in the two-dimensional plots that CX3CR1+ T cells do not express the respective chemokine receptors (...