Peripheral T cell lymphomaImmunosenescenceCD4-positive cytotoxic T cellsT cell lymphoproliferative disorders that arise in the skin are mainly derived from post thymic T cells most commonly of CD4 subset. Human
Memory CD4+ T cells: fate determination, positive feedback and plasticity. Cell Mol. Life Sci. 69, 1577–1583 (2012). CAS PubMed PubMed Central Google Scholar Perrigoue, J.G. et al. MHC class II-dependent basophil-CD4+ T cell interactions promote TH2 cytokine-dependent immunity. Nat....
and ultimately export to the periphery, where they play important roles in the peripheral tissues and various lymphatic organs. Progenitor cells lacking CD4+and CD8+receptors in the bone marrow generate CD4+CD8+double-positive (DP) thymocytes via T cell receptor (TCR) rearrangement. DP cells under...
CD4+ T-cell-mediated rejection of MHC class II-positive tumor cells is dependent on antigen secretion and indirect presentation on host APCs. Cancer Res. 78, 4573–4585 (2018). Article CAS PubMed Google Scholar Seliger, B., Kloor, M. & Ferrone, S. HLA class II antigen-processing ...
Establishment of a CD4-positive cell line from an AIDS-related pri- mary effusion lymphoma. Int J Hematol 2013; 97: 624-33; PMID:23605439; http://dx.doi.org/10.1007/ s12185-013-1339-3Goto H, Kojima Y, Nagai H, Okada S. Establishment of a CD4-positive cell line from an AIDS-...
Furthermore, quantitative analysis of Th1 and Th2 cytokine mRNA expression in the cutaneous T cell lymphoma cell line as well as in TC5 and TC7 clones indicated that, whereas the tumor cells display a Th2-type profile (interleukin-4, interleukin-6, and interleukin-10), the cytotoxic T ...
Leuk Lymphoma 2004, 45:1959–1967. 3. Kuo CT, Veselits ML, Leiden JM: LKLF: a transcriptional regulator of single- positive T cell quiescence and survival. Science 1997, 277:1986–1990. 4. Buckley AF, Kuo CT, Leiden JM: Transcription factor LKLF is sufficient to program T cell ...
Both CD8+ T-cells as well as Natural Killer (NK) cells are key effector cells in eliminating virus-infected cells [9, 10]. For EBV it has been shown that incorporating T-cell reconstitution data increases the positive predictive value for development of EBV-PTLD [11]. Also for CMV, ...
讨论 原发性皮肤 CD4+小/中等大 T 细胞淋巴瘤(pri-mary cutaneous CD4+small/medium T-cell lymphoma,PCSM-TCL)是一种罕见的原发性皮肤 T 细胞淋巴瘤,占原发性皮肤淋巴瘤的 2% ～ 3% [1] 。在 2005 年世界卫生组织和欧洲癌症研究与治疗组织(World Health Organization-EuropeanOrganization for Research and...
Immunoglobulin and T-cell receptor gene rearrangements in Hodgkin's disease and Ki-1-positive anaplastic large cell lymphoma: dissociation between phenotyp... We have determined the tumor cell immunophenotype and the rearrangement configuration of immunoglobulin and T-cell receptor genes in 39 cases of...