Definition Are CD4 T cells that can help B cells to make antibody in response to antigenic challenge. The most efficient helper T cells are also known as Th2 cells, which make the cytokines IL-4 and IL-5. Some experts refer to all CD4 T cells, regardless of function, as helper T ...
et al. A cytokine-independent approach to identify antigen-specific human germinal center T follicular helper cells and rare antigen-specific CD4+ T cells in blood. J. Immunol. 197, 983–993 (2016). Article CAS PubMed Google Scholar Grifoni, A. et al. Targets of T cell responses to ...
Helper CD4+ T cells are important in mediating protective humoral immunity by stimulating B cells to produce virus-specific antibodies. On the other hand, CD8+ T cells are responsible for theelimination of infected cells,mainly through the production of perforin and granzyme, and are key players ...
cells (PIC-seq) and find that CD4+PD-1+CXCL13+T cells are a major interacting hub with antigen-presenting cells in the tumor microenvironment of human non-small cell lung carcinoma. We define this clonally expanded, tumor-specific and conserved T-cell subset as T-helper tumor (Tht) cells...
When OKT4monoclonal antibodiesare used to identify T-helper cells, falsely low CD4 + cell counts are observed in up to 11% of Blacks (and in lesser numbers of Asians and Caucasians) who lack or have a partial deficiency of the OKT4 epitope (34–36). These individuals may appear to have...
The CD4 antigen is involved in the recognition of MHC class II molecules and is a co-receptor for HIV. CD4 is primarily expressed in a subset of T-lymphocytes, also referred to as T helper cells, but may also be expressed by other cells in the immune system, such as monocytes, macropha...
4a), we reasoned that CLTCH129>Q-specific CD4+ T cell-mediated protection may be dependent on their role as helper cells for CD8+ T cells19. Consistent with this, depletion of CD8+ T cells before the transfer of CD4+ T cells and tumor inoculation prevented tumor rejection (Fig. 4f). ...
LCs were significantly more efficient than CD1c+DDCs at inducing allogeneic naive CD4+ T cells to secrete both T helper cell 1 (Th1; IFN-γ and tumor necrosis factor-α ) and Th2 (IL-4 and IL-5) cytokines. Moreover, anti-PD-L1 mAb increased the production of IFN-γ by both LC-...
ATP concentration of CD4+ T-Cells a predictive biomarker of im- mune status in stable transplant recipients? Transplantation,2009, 88:S78-84 [ 6] Serban G, Whittaker V, Fan J, et al Significance of immune cell function monitoring in renal transplantation after Thymoglobulin ...
Pathogenic T helper type 2 cells (pTh2) are involved in allergic asthma and secrete high levels of IL-5 and IL-13. Here, using HDM challenged mice and developing an in vitro pTh2 culture system, the authors investigate the function of epigenetic modifications in pTh2 cells showing that HDAC...