CD4 T细胞通常也称为辅助性T淋巴细胞(CD4 Helper T Cells),它的成长经历和CD8 T细胞一样,也是在胸腺由淋巴祖细胞经过克隆选择/双阴/双阳等层层筛选分化而成。 与CD8 T细胞活化需要MHCI-抗原复合体不同,CD4 T细胞活化第一信号来自MHCII-抗原复合体。 之所以说CD4 T细胞具有多重人格,主要是不同于钢铁直男CD8 T细胞...
Follicular T-helper cellsHIV infectionsViral immune evasionAnalysis of the whole-genome transcriptional activity of HIV-specific CD4+ T cells demonstrates distinct profiles associated with natural control of HIV replication, as well as dysfunctional phenotypes that persist even after effective antiretroviral ...
Helper CD4+ T cells are important in mediating protective humoral immunity by stimulating B cells to produce virus-specific antibodies. On the other hand, CD8+ T cells are responsible for theelimination of infected cells,mainly through the production of perforin and granzyme, and are key players ...
inerleukin 17 pro-ducing cd4+effector t cells develop via a lineage distinct from the t helper type 1 and 2 lineages [j]. nat immunol , 6 ( 11): 1123-1132. [5]tartour e., et al., (1999) interleukin 17,a t-cell derivedcytokine,promotes tumor...
et al. Single naive CD4+ T cells from a diverse repertoire produce different effector cell types during infection. Cell 153, 785–796 (2013). Article CAS PubMed PubMed Central Google Scholar Swarnalekha, N. et al. T resident helper cells promote humoral responses in the lung. Sci. ...
T-helper 17 cells T-helper 2 cells Latest Research and Reviews ZFP36-family RNA-binding proteins in regulatory T cells reinforce immune homeostasis RNA binding proteins have been shown to alter the function of various immune cells. Here the authors show that ZFP36-family RNA binding proteins...
STAT5 has been reported to be a master regulator of energy and amino acid metabolism in CD4 T helper cells in order to accommodate for the high energy demand of T cell activation and proliferation, characterized by IL-2–mediated mTOR signaling and promoted Myc-driven metabolic changes54. Thus...
The CD4 antigen is involved in the recognition of MHC class II molecules and is a co-receptor for HIV. CD4 is primarily expressed in a subset of T-lymphocytes, also referred to as T helper cells, but may also be expressed by other cells in the immune system, such as monocytes, macropha...
The percentage of HIV-1–infected CD4+ T cells is too low to account for the extensive depletion of T-helper cells in patients who are chronically infected with HIV-1 and progressing to AIDS.39,40 Thus, it was suggested that uninfected CD4+ T cells die by apoptosis during HIV-1 disease...
To determine whether upregulation of CCR5 by IFNα could compromise the inhibitory effect of IFNα on HIV-1 replication, cells were pretreated with three different concentrations of IFNα (0.2 ng/mL, 1 ng/mL, 5 ng/mL) during the stimulation step. Cells stimulated in the absence of...