HIV compromises immunological function by attacking cells (CD4+ T-cells) that play an essential role in protecting the host from pathogens3. Once HIV destroys these cells, it becomes harder for the body to fight off other infections. Unprotected sexual contact, hypodermic needles, contaminated blood...
Greene团队在Cell杂志上发表文章Attacking Latent HIV with convertible CAR-T Cells, a Highly Adaptable Killing Platform,报道了一种新型可转换型CAR-T细胞平台,即将CTL与一系列广谱的抗HIV抗体进行结合,并证明了可转换型CAR-T平台只有与抗HIV抗体结合时,才能够高效地特异性地击杀血液、扁桃体和脾脏中HIV感染的CD4+...
Because the cCAR-T system is a two-part modular system, one of its advantages is the ability to multiplex with different MicAbodies, thus attacking the virus-infected cells with more than one type of bNAb. To confirm effective multiplexing with cCAR-T, we armed these cells with two ...
Eytan Herzig,et al.Attacking Latent HIV with convertibleCAR-T Cells, a Highly Adaptable Killing Platform.Cell.发布于 2019-10-31 11:26 艾滋病 导弹 HIV 赞同24 条评论 分享喜欢收藏申请转载 写下你的评论... 4 条评论 默认 最新 永不言败 要想办法研究可以全愈的...
If left untreated, within 8 to 12 years, the virus progresses to stage 3, AIDS. Here, symptoms appear where the virus is attacking the immune system, like swollen lymph glands; a fungal infection of the mouth called candidiasis or thrush; skin...
Herzig E, Kim KC, Packard TA, Vardi N, Schwarzer R, Gramatica A, Deeks SG, Williams SR, Landgraf K, Killeen N, Martin DW, Weinberger LS, Greene WC (2019) Attacking latent HIV with convertibleCAR-T Cells, a highly adaptable killing platform. Cell 179:880-894.e10. https://doi.org/...
(生物通:万纹) 原文标题: Attacking Latent HIV with convertibleCAR cells, a Highly Adaptable Killing Platform
Protease inhibitors: while the explanation is difficult, these medications also prevent the virus from making additional copies of itself and attacking cells Integrase inhibitors: they disable a protein called integrase that HIV needs to inject its genetic material in cells ...
The progressive loss of CD4+ T cells during HIV infection of lymphoid tissues involves both the apoptotic death of activated and productively infected CD4 T cells and the pyroptotic death of large numbers of resting and abortively infected bystander CD4 T cells. HIV spreads both through cellular ...
HIV is a retrovirus that weakens the body's immune system by infecting and replicating in CD4+T-cells (Morris & Cilliers, 2008 ). CD4+T-cells stimulate lymphocytes that assist the body in attacking antigens and fighting off disease. When HIV infection occurs, the virus gains entry to host...