We visualized the colocalization of marker-eQTLs and markers of PTB and COVID-19 genome-wide association study (GWAS) associations. Based on CellChat analyses, monocytes communicated predominantly with CD4+ TEM
defined as CCR7+CD45RO−CD27+, were concatenated and analyzed by t-SNE. Clusters were visualized by phenograph.bPhenotype of naive CD4 T-cell clusters. The intensity of fluorescence for each marker was visualized by a normalized
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Here, we mapped genetic effects on gene expression (expression quantitative trait loci (eQTLs)) using single-cell transcriptomics. We profiled 655,349 CD4+ T cells, capturing transcriptional states of unstimulated cells and three time points of cell activation in 119 healthy individuals. This ...
. journal of the international aids society, 2016, 19(1).Sainz, Talía, Serrano-Villar S , Díaz, Laura, et al. The CD4/CD8 ratio as a marker T-cell activation, senescence and activation/exhaustion in treated HIV-infected children and young adults[J]. Aids, 2013, 27(9):1513-1516.
胎儿肠道组织中CD4+Tem细胞表达CD69和CD103,但programmed cell death 1 (PD1)低表达 首先CD69和CD103代表T细胞是否anchored in tissues,而PD1大家比较熟知的是作为肿瘤治疗中的PD1抑制剂,可以激活机体免疫系统,同理,胎儿肠道组织中PD1持续低表达,表示CD4+T细胞在胎儿期肠道组织中非常活跃( ...
相关指标marker选择: 脱颗粒相关:LAMP、LAMP-1(CD107a)、LAMP-2(CD107b) 分泌的因子:Granzyme B、Perforin、IFN-γ、TNF-a、IL-2 相关受体:NKG2A/CD94(抑制)、NKG2D(活化)、CD95/FasL、FCRL6 转录因子:T-bet、Eomes、Bcl-2 其他:CD27、CD28、CD57 健康人CD4+CTL的标记: 表面标记:CD11a+, CD11b+,...
近日，明尼苏达大学David Masopust在Nature Immunology上发表了题为 CD4+ T cell memory 的综述论文，对记忆CD4+ T细胞进行了系统性综述。记忆CD4+ T细胞的寿命和检测手段 有研究显示，在接种天花疫苗后75年，记忆CD4+ T细胞在体外经抗原特异性肽段的再刺激后仍能产生IFN-γ。麻疹疫苗接种后至少34年、麻腮风疫苗接种...
发表在 Cancer Cell 期刊的 “Neoantigen -specifc CD4T cells in human melanoma have diverse diferentiation states and correlate with CD8+Tcel,macrophage,and Bce function”,该研究系统性的分析了漫润黑色素瘤的肿瘤抗原特异性CD4+ T细胞 亚群的转录组特征,并分析其与患者存活率以及肿瘤微环境中其他免疫细胞...
近日,明尼苏达大学David Masopust在Nature Immunology上发表了题为CD4+ T cell memory的综述论文,对记忆CD4+ T细胞进行了系统性综述。 记忆CD4+ T细胞的寿命和检测手段 有研究显示,在接种天花疫苗后75年,记忆CD4+ T细胞在体外经抗原特异性肽段的再刺激后仍能产生IFN-...