在这篇短文里,我们就通过简单的分析,在单细胞数据中发现一个有趣的现象:CD4基因在Monocyte中高表达,而且表达量还可能比在CD4+T细胞还高。 图5:单细胞测序流程图 基于BD公司平台的单细胞转录组和表面蛋白同时检测的数据,我们可以看到Monocyte虽然在mRNA水平高表达CD4,但是在蛋白水平基本 不表达CD4。这揭示了转录后调...
在这篇短文里,我们就通过简单的分析,在单细胞数据中发现一个有趣的现象:CD4基因在Monocyte中高表达,而且表达量还可能比在CD4+T细胞还高。 基于BD Biosciences的单细胞转录组和表面蛋白同时检测的数据,我们可以看到Monocyte虽然在mRNA水平高表达CD4,但是在蛋白水平基本不表达CD4。这揭示了转录后调控研究的重要性。 本文...
Conclusion: Our data support a model of highly activated monocytes and CD4(+)T cells associated with inflammation in chronic HIV-1 infection, but impaired monocyte anti-inflammatory responses in HAND compared with cognitively normal.Sharma, VishakhaBryant, ChristopherMontero, MariaCreegan, MatthewSlike,...
Elevation of IFN-alpha, IFN-gamma, monocyte chemoattractant protein (MCP)-1, soluble IL-2 receptor (sCD25), IL-6 and IL-8 was seen in chronically infected untreated individuals (63, 70, 71). CD4 T细胞集团细胞数量取值是2千亿。正常的CD4 T细胞集团细胞数量取值是时间轴稳定不变的。 Quantitative...
Identified CD4+ cells expressing a monocyte/macrophage surface marker (CSF-1R) Identified CD4-1/CD4-2 double-positive T cells, CD4-1 single-positive T cells, and CD4-2 single-positive T cells [12] CD4-1/CD4-2 double-positive T cells comprised majority of CD4+ T cell subpopulations Japanes...
Different batches of ab133616 were tested on THP-1 (Human monocytic leukemia monocyte) lysate at 1.0 µg/ml. 15 µg of lysate was loaded in each lane. Bands observed at 51 kDa. Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human thymoma tissue labelling ...
adaptive immune response induction by virus of host cell-cell fusion cell adhesion T cell differentiation macrophage differentiation maintenance of protein location in cell positive regulation of I-kappaB kinase/NF-kappaB signaling T cell selection positive regulation of monocyte differentiation positive ...
First, I will examine how CD4 T cell responses are initiated, by analyzing recruitment of inflammatory monocytes to the infected lung and measuring how monocyte-derived dendritic cells instruct the activation and differentiation of tuberculosis-specific CD4 T cells. Second, I will examine which ...
(1990) Comparison of SIV/ SMM replication in CD4+ T cell and monocyte/macrophage cultures from rhesus macaques and sooty mangabeys. J. Med. Primatol. 19. 251-267.T. Yehuda-Cohen, J.D. Powell, F. Villinger, H.M. McClure, K.W. Sell & A. Ahmed-Ansari: Comparison of SIV/SMM ...
are consistent with antigen recognition. Of the MHCII+immune cells adherent in glomerular capillaries, only monocytes are retained for prolonged durations. These cells can also induce T-cell proliferation in vitro. Moreover, monocyte depletion reduces CD4+T-cell-dependent glomerular inflammation. These...