在早期NSCLC患者中,再次没有观察到总CD8+T细胞浸润与之前新辅助化疗的差异;然而,新辅助免疫疗法确实增加了总CD8+T细胞的浸润(图5E)。与没有接受新辅助治疗的患者相比,接受新辅助化疗的患者CD8+T细胞的%CD39+减少;相反,在接受新辅助ICB的...
在人类免疫缺陷病毒(human immunodeficiency virus,HIV)感染中,CD8+T细胞对于病毒的清除至关重要【1】。因此,CD8+T细胞生物学动态与HIV感染患者息息相关。在慢性感染和肿瘤中,持续的抗原刺激诱导耗竭性T细胞(exhausted T cell,Tx)的...
近日来自新加坡中央医院及国家癌症中心的研究团队使用生物多组学研究手段在Journal of Thoracic Oncology 发表论文Intratumoral CD39+CD8+ T Cells Predict Response to Programmed Cell Death Protein-1 or Programmed Death Ligand-1 Blockade in Patients With NSCLC 揭示CD39+CD8+T细胞在非小细胞肺癌的免疫治疗效果预测...
7. Morgan A, Reuter., Perla M, Del Rio Estrada., Marcus, Buggert., Constantinos, Petrovas., Sara, et al. (2017). HIV-Specific CD8(+) T Cells Exhibit Reduced and Differentially Regulated Cytolytic Activity in Lymphoid Tissue. Cell Rep, 21(12), 0. doi:10.1016/j.celrep.2017.11.075 ...
b Upperpanel: t-SNE plots of the main T cell subsets. Lower left panel: frequency ofthe main T cell subsets in both groups. Each symbol represents an individualmouse, *p=0.019 (CD4+ Tconv), *p=0.011(CD8+ T cells). Lower right panel: Heat map with markerexpression of the main T ...
Partially confirming recent observations correlating the CD39 expression with T-cell exhaustion, we demonstrated a divergent functional activity in CD39+ CD8+ TILs. On the one hand, CD39+ CD8+ TILs (as compared to their CD39- counterparts) produced significantly lower IFN-纬 and IL-2 amounts...
tTex cell suppression requires CD39, which generates immunosuppressive adenosine. Restricted deletion of CD39 in endogenous CD8+ T cells resulted in slowed tumor progression, improved immunotherapy responsiveness and enhanced infiltration of transferred tumor-specific T cells. CD39 is induced on tTex ...
表1清晰总结了CD39在肿瘤微环境中的巨噬细胞、骨髓来源的抑制性细胞(MDSCs)、嗜中性粒细胞、CD4+或CD8+效应T细胞、调节性T细胞(Tregs)、TH17细胞、NK细胞以及抗原递呈细胞中的作用,以及这些细胞对CD39抑制剂的响应。 二、CD39抑制剂的作用机制 图2 来源:Nature Reviews Immunology ...
CD39 ectonucleotidase is the rate-limiting enzyme of a cascade leading to the generation of suppressive adenosine that alters CD4 and CD8 T cell and natural killer cell antitumor activities. CD39用户评价 公司简介 百普赛斯集团ACROBiosystems Group(股票代码:301080)是成立于2010年的跨国生物科技公司,是...
Treg细胞可以通过分泌IL-10来发挥抑制作用,先前也有研究发现了一群分泌IL-10的CD8 T细胞[5]。然而Il10敲除的tTex细胞与野生型tTex细胞有着相似的抑制功能,说明tTex细胞并非通过IL-10发挥抑制功能。 先前的研究还表明,Treg细胞上高表达的CD39和CD73可以将凋亡细胞释放的ATP水解为腺苷,从而发挥抑制功能[6]。在人和小...