Human tumor CD39 + Tconv cells constituted a heterogeneous cell population with features of exhaustion, high expression of inhibitory receptors and CD107a. We found that high CD4 and ENTPD1 (CD39) gene expression in human tumor tissues correlated with a higher overall survival rate in breast ...
该酶在多种人类肿瘤中高表达,包括淋巴瘤、肉瘤、慢性淋巴细胞白血病、肺癌、胰腺癌、卵巢癌、肾癌、甲状腺癌和睾丸癌。虽然在某些情况下,与正常细胞相比,肿瘤细胞会过表达CD39,但在肿瘤微环境中,最一致高表达CD39的细胞类型是血管内皮细胞、成纤维细胞和几个亚群的免疫细胞,包括NK细胞、CD4+CD25+调节性T(Treg)细胞...
该酶在多种人类肿瘤中高表达,包括淋巴瘤、肉瘤、慢性淋巴细胞白血病、肺癌、胰腺癌、卵巢癌、肾癌、甲状腺癌和睾丸癌。虽然在某些情况下,与正常细胞相比,肿瘤细胞会过表达CD39,但在肿瘤微环境中,最一致高表达CD39的细胞类型是血管内皮细胞、成纤维细胞和几个亚群的免疫细胞,包括NK细胞、CD4+CD25+调节性T(Treg)细胞...
若 DP 细胞的 TCRαβ 能与胸腺皮质细胞表面 MHC-II 或 MHC-I 类分子以适当亲和力结合,即继续分化为 CD4+ 或 CD8+单阳性细胞(single positive cell,SP):与基质细胞表面 MHC-I 类分子结合的 DP 细胞其 CD8 表达水平增高,CD4 表达水平下降直至丢失;与 ...
22.在又另一方面中,提供一种用于促进免疫细胞浸润至肿瘤内的方法,所述方法包括向患有肿瘤的受试者施用有效量的本文描述的抗cd39抗体或其抗原结合片段的药物组合物,其中所述抗cd39抗体或其抗原结合片段的施用使得肿瘤中的cd39+cd45-sca-1+基质细胞消除和减少,并且细胞毒性t细胞对肿瘤的浸润增加。23.在又另...
CD39 inhibits T-cell and Natural killer (NK) cell responses by hydrolyzing ade-nosine triphosphate and adenosine diphosphate, suppressing the immune system. We investigated expression of CD39 on CD4+ T Lymphocytes in chronic lymphocytic leukemia (CLL) patients and its relationship with deletion 6q,...
49.图35提供了一个图表,所述图表描绘了用抗cd39/tgfβ陷阱分子es014-1和es014-2、抗cd39抗体es014_v2、tgfβ陷阱es014_v1和对照抗体es014_v3处理的总t细胞的百分比(%),如图所示。图35a显示了cd4 + t细胞的百分比(%),以及图35b显示了cd8 +
All these CD73+ T cell subsets and B cells hydrolyzed 5′-AMP to ADO. Exosomes isolated from plasma of normal control (NC) or cancer patients carried enzymatically active CD39 and CD73+ and, when supplied with eATP, hydrolyzed it to ADO. Only CD4+CD39+ Treg co-incubated with CD4+CD...
结论:CD4q"细胞表达的CD39和CD73在过敏性哮喘免疫反应过程中起到重要作用关键词:过敏性哮喘;CD4~T细胞;CD39;CD73中图分类号:R562.25文献识别码:A文章编号:1673.6087(2014)02—0130—04DOI:10.3969/j.issn.1673.6087.2014.02.011ExpressionofCD39andCD73byCD4+Tcellsinperipheralbloodofpatientswithallergicasthmaand...
5. Extracellular adenosine and the adenosine A2A receptor promote T cell tolerance and regulatory T cells [D] . Zarek, Paul E. 2008 机译:细胞外腺苷和腺苷A2A受体促进T细胞耐受性和调节性T细胞 6. Human CD4+CD39+ regulatory T cells produce adenosine upon co-expression of surface CD73 or ...