CD33+ populations within the TME are enriched for HLA-DR– populations and comprise different MDSC sub- sets, including C D33+HLA-DR–CD14+CD15– monocytic MDSCs, CD33+CD14+CD15– polymorphonuclear MDSCs and CD33+HLA-DR–CD14–CD15– immature or early-stage MDSCs [32]. Since...
Immature myeloid cells (HLA-DR−/lowCD33+CD16−) were tested before and after granulocyte colony-stimulating factor (G-CSF) administration in healthy donor and isolated for suppression assays and co-culture with T cells in vitro. Isolated cells were infused in humanized mice for a xenogeneic ...
Some third parties are outside of the European Economic Area, with varying standards of data protection. See our privacy policy for more information on the use of your personal data. Manage preferences for further information and to change your choices. Accept all cookies ...
Here, we focus on the importance in caution when interpreting MDR in AML. Bone marrow (BM) sample was assessed toFLT3andNPM1mutation,RUNX1/RUNX1T1andCBFB-MYH11rearrangements, karyotype (KT) and immunophenotyping. Using an 8-colour antibody panel (CD45, CD34, CD117, CD 33, HLA-DR, CD38...
(MDSCs) are broadly classified as either neutrophilic or MO MDSCs, and are phenotypically identified as being CD11b+CD15+CD66b+CD33+CD14−or CD11b+CD15−CD33+CD14+HLA-DR-/low, respectively5,6,7,8. In our previous studies, we observed a subset of immunosuppressive myeloid cells in ...