三个强劲靶点直击AML— CD33,CD123,CLEC12A (Acute Myeloid Leukemia,AML)是一种髓系造血干/祖细胞恶性疾病,长期以来,一直采用蒽环类和阿糖胞苷化疗治疗轻度患者,使用造血干细胞转移来治疗中、高危患者,其中,老年患者(≥60岁)和临床表现不佳的患者死亡率较高,5年总生存率约为10%。由于急性髓细胞白血病的异质性,导...
由于过继转移的自然杀伤(NK)细胞寿命较短,副作用较少,并且对AML具有内在的CAR非依赖性杀伤能力,因此CD33-CAR-NK细胞就成了一种有前景的替代品。 2022年4月,Blood cancer journal期刊上发表了题为“Primary CD33-targeting CAR-NK cells ...
数量 38 包装规格 48T/96T 标记物 详见说明书 纯度 % 样本 Myeloid cell surface antigen CD33 ELISA Kit 应用 ELISA 是否进口 是标本要求 1.标本采集后尽早进行提取,提取按相关文献进行,提取后应尽快进行实验。若不能马上进行试验,可将标本放于-20℃保存,但应避免反复冻融。 2.不能检测含NaN3的样品...
Siglec 3 expression is restricted to cells of myelomonocytic lineage. Siglec3 recruits SHP1 and SHP2 to its ITIMs upon phosphorylation. 英文别名: Myeloid Cell Surface Antigen CD33, Sialic Acid-Binding Ig-Like Lectin 3, Siglec-3, gp67, CD33, SIGLEC3 描述: Recombinant Human Sialic Acid Binding...
Vitale,C.et al.(2001).″Surface expression and function of p75/AIRM-1or CD33in acute myeloid leukemias:engagement of CD33 induces apoptosis of leukemic cells″.PNAS 98:5764-5769. 序列表 <110> 塞勒克提斯公司 <120> 用于癌症免疫治疗的CD33特异性嵌合抗原受体 <130> P81401908PCT00 <150> PA2014...
近日,加利福尼亚大学洛杉矶分校(University of California, Los Angeles)的研究人员在《Nature Communications》期刊上发表了题为 “Allogeneic CD33-directed CAR-NKT cells for the treatment of bone marrow-resident myeloid malignancies” 的论文。该研究开发出一种用于治疗骨髓源性髓系恶性肿瘤的新型免疫细胞疗法 —...
3. Shim H, Ha J H, Lee H, et al. Expression of Myeloid Antigen in Neoplastic Plasma Cells Is Related to Adverse Prognosis in Patients with Multiple Myeloma[J]. Biomed Res Int, 2014, 2014:893243-893251. 4. Mateo G, Castellanos M, Rasillo ...
参考文献: [1]Albinger, N., Pfeifer, R., Nitsche, M. et al. Primary CD33-targeting CAR-NK cells for the treatment of acute myeloid leukemia. Blood Cancer J. 12, 61 (2022).
cells of myelomonocytic lineage, binds sialic acid residues in N- and O-glycans on cell surfaces, and is a therapeutic target for acute myeloid leukemia. Further, CD33 is found on granulocyte and macrophage precursors in the bone marrow, but is not on pluripotent stem cells. CD33 is also ...
别名 CD33/Myeloid cell surface antigen CD33/Sialic acid-binding Ig-like lectin 3/Siglec-3/Siglec3 形态 Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.4. 来源 Human Cells 氨基酸序列 DLEFQLVAPESVTVEEGLCVHVPCSVFYPSIKLTLGPVTGSWLRKGVSLHEDSPVATSDPRQLVQ KATQGRFQLLGDPQKHDC...