关键词 :再生障碍性贫血 ;CD25;HLA-DR;辨证分型;判别分析 中图分类号 :R241 文献标识码:B 文章编号 :1006-3250(2006)11-0850-03Research on Relationship between Expression of CD3+ CD25 +andCD3 + HLA-DR + T Cell Subsets and TCM DifferentiationType in Patients of Aplastic AnemiaTANG Xu-dong, ...
关键词:再生障碍性贫血;CD25;HLA.DR;辨证分型;判别分析中圈分类号:R241文献标识码:B文章编号:1006.3250(2006)11-0850-03ResearchonRelationshipbetweenExpressionofCD3CD25andCD3HLADRTCellSubsetsandTCMDifferentiationTypeinPatientsofAplasticAnemiaTANGXu—dong,MARou,LIUFeng。XUYong—gang,YANGXiao—hong(National...
CD3 双特异抗体虽然在血液瘤中取得了丰硕成果,但是在实体瘤中还有很多挑战,这些挑战包括:1)On-target off-tumor 毒性;2)肿瘤微环境中(TME)的效应细胞的数量有限;3)肿瘤中 T 细胞活性被抑制。 个人认为这些挑战也是层层递进的关系,On-target off-tumor 毒性和肿...
HLA-DR、CD95和细胞内细胞毒T淋巴细胞相关抗原4(CTLA-4)的表达水平.应用实时荧光定量RT-PCR检测CD4+ CD25+、CD4+ CD25-、CD4+和CD4-等细胞亚群和外周血单个... 福军亮,徐东平,施明,... - 《中华内科杂志》 被引量: 51发表: 2006年 HLA-DR Antigen Expression on Peripheral T Cell Subsets in Pityriasis...
①Cell：ITPRIPL1 binds CD3ε to impede T-cell activation and enable tumor immune evasion 全新肿瘤免疫检查点ITPRIPL1（CD3L1）通过结合CD3ε抑制肿瘤微环境中的T细胞 DOI: 10.1016/j.cell.2024.03.019 该研究发现CD3的首个配体CD3L1（或ITPRIPL1），作为CD3ε的抑制性配体，CD3L1是一个全新的免疫检查点...
PROGRAMMED cell death 1 receptorsBackground: The search for biomarkers to identify ideal candidates for immune checkpoint inhibitor (ICI) therapy is fundamental. In this study, we analyze peripheral blood CD3+HLADR+ cells (activated T-cells) as a novel biomarker for ICI therapy ...
Purified CD14+HLA-DRlo cells suppressed in vitro T-cell proliferation in a concentration-dependent manner allowing us their denomination as MDSCs. Interestingly, we also observed that primary AML blasts and human AML cell lines (THP, OCI-AML, and HL-60) induced HLA-DRlo cells from healthy ...
In addition, CD64-CR T cells exhibit strong immunoregulatory functions since they induce the upregulation of programmed death-ligand 1 (PD-L1) and de novo expression of HLA-DR on cancer cells through the specific production of IFNγ. Remarkably, CD64-CR-T-cell cytotoxicity was enhanced in ...
role in TCR-induced growth arrest, cell survival and proliferation. The CD3 antigen is present on 68-82% of normal peripheral blood lymphocytes, 65-85% of thymocytes and Purkinje cells in the cerebellum. It is never expressed on B or NK cells. Decreased percentages of T lymphocytes may be ...
DR (HLA-DR), potentially identifies a regulatory T cell population. Using an allogeneic mixed lymphocyte culture (MLC) to induce an antigen-specific immune response, the role of antigen-presenting cells (APCs) for the presence of HLA-DR on cluster of differentiation 3(CD3)+ CD4+ T cells ...