Fast and efficient depletion of CD3+ T cells from any sample. About Dynabeads CD3 Dynabeads CD3 are uniform, superparamagnetic beads (4.5 μm diameter) coated with a primary monoclonal antibody specific for the CD3 membrane antigen mainly expressed mainly on human mature T cells. Because of the ...
Pharmacology Muromonab CD3 is a purified murine monoclonal antibody directed against the CD3 antigen, which is found on all mature human T cells. It reacts only with human T cells and those from higher primates such as chimpanzee but not with other human tissues. It is an IgG 2a ...
Dynabeads® CD3 are uniform, superparamagnetic beads (4.5 µm diameter) coated with a primary monoclonal antibody specific for the CD3 membrane antigen mainly expressed mainly on human mature T cells. Because of the bead size, Dynabeads® CD3 can easily and efficiently isolate or deplete cells...
Thymocytes (differentiation dependent), mature T cells, NK-T cells Function Antigen recognition, TCR signal transduction, T cell activation Ligand/Receptor Peptide antigen/MHC-complex Antigen References 1. Barclay A, et al. 1997. The Leukocyte Antigen FactsBook Academic Press. 2. Davis MM....
CD3 antigen can be found bound to the membranes of all mature T-cells and in virtually no other cell type. This high specificity, combined with its presence at all stages of T-cell development makes it a useful T-cell marker for IHC tissue sections. The antigen is also present in almost...
the epsilon chain is required for proper assembly, trafficking and surface expression of the TCR complex. CD3 is expressed by thymocytes in a developmentally regulated manner and by all mature T cells. Crosslinking of TCR with HIT3a initiates an intracellular biochemical pathway resulting in cellular...
It is found on all mature T lymphocytes, NK-T cells, and some thymocytes. CD3, also known as T3, is a member of the immunoglobulin superfamily that plays a role in antigen recognition, signal transduction, and T cell activation. Other Names: T3, CD3ε Structure: Ig superfamily, with the...
CD3 is a complex structure composed of three differentpolypeptidedimmers: γɛ, δɛ, and ζζ. CD3 in conjunction with T-cell receptor (TCR) makes theTCRcomplex TCR molecules represent two differentheterodimers: αβ and γδ. The vast majority of matureT cellsbear TCR αβ, whereas onl...
Detects mouse CD3. Recognizes mouse T cell receptor-associated CD3 complex that is expressed on thymocytes and mature T cells. storage : Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C...
In this system CD4+ T cells, but not B cells, were rendered tolerant and effectively transferred such tolerance to naïve hosts. The single caveat is that only high CD4 mAb dosages are tolerogenic. In the mouse anti-CD4 affords tolerance also to alloantigens (anti-CD4 mAbs are effe...