Fast and efficient depletion of CD3+T cells from any sample. About Dynabeads CD3 Dynabeads CD3 are uniform, superparamagnetic beads (4.5 μm diameter) coated with a primary monoclonal antibody specific for the CD3 membrane antigen mainly expressed mainly on human mature T cells. Because of the be...
Differential activation of CD8+ T cells by transforming growth factor-beta 1. TGF-beta 1 also down-regulated CD45RB and increased CD44 expression on responsive CD8+ and CD45RBhi T cells, thereby leading to a population of T cells enriched in mature phenotype. Generation of anti-CD3-redirected...
(1998) Phosphoantigen activation induces surface translocation of intracellular CD94/NKG2A class I receptor on CD94- peripheral Vgamma9 Vdelta2 T cells but not on CD94- thymic or mature gammadelta T cell clones. Eur J Immunol 28: 3399–3410. [36] Constant P, Davodeau F, Peyrat MA, ...
One major role of the thymus is to provide the peripheral immune system with mature T cells, but the mechanisms involving the cellular export are not fully... H Yagi,R Kamba,K Chiba,... - 《European Journal of Immunology》 被引量: 232发表: 2000年 Enhancement of calcium signaling and pr...
CD3 antigen can be found bound to the membranes of all mature T-cells and in virtually no other cell type. This high specificity, combined with its presence at all stages ofT-celldevelopment makes it a useful T-cell marker for IHC tissue sections. The antigen is also present in almost all...
CD3 is a complex structure composed of three differentpolypeptidedimmers: γɛ, δɛ, and ζζ. CD3 in conjunction with T-cell receptor (TCR) makes theTCRcomplex TCR molecules represent two differentheterodimers: αβ and γδ. The vast majority of matureT cellsbear TCR αβ, whereas onl...
CD3 is expressed by thymocytes in a developmentally regulated manner and by all mature T cells. Crosslinking of TCR via immobilized UCHT1 initiates an intracellular biochemical pathway resulting in cellular activation and proliferation.Applications Reported: This UCHT1 antibody has been reported for use...
T-cell activation by HER2-XPAT protein and its proteolytically activated unmasked HER2-TCE was characterized utilizing primary huPBMCs co-cultured with SKOV3 tumor cells (HER2-high). Incubation with unmasked HER2-TCE for 72 h led to dose-dependent upregulation of the activation marker CD69 on...
CD3 molecules are mainly distributed on the membrane of mature T cells. They are involved in T cell antigen recognition, signal transduction, and regulation of T cell development. CD3-related monoclonal antibodies (mAbs) are mainly used in the treatment of autoimmune diseases. Nearly half of all...
Amongst peripheral T cells, a small proportion of CD7- cells were detected, within both the CD4+8-3+ and the CD4-8+3+ categories. Finally, in contrast to previous conclusions, CD1a was expressed at high levels on mature (CD4+8-3+ and CD4-8+3+) human thymocytes, although in ...