T cellsINTERLEUKIN-10IMMUNE responseTUBERCULOSIS patientsPROTEIN expressionEvidence indicates that more than 90 % of infected individuals never develop active tuberculosis. This fact highlights the relevance of the immune response in tuberculosis control. The inducible co-stimulator (...
OKT3 is a murine IgG2a mAb targeting the ε chain of the CD3:T-cell receptor complex and was first approved for the treatment of rejection. Soon after OKT3 administration, T cells disappear from circulation as a result of opsonization and subsequent removal from circulation by mononuclear ...
(HLA).Approach and ResultsImmTAV molecules specific for HLA‐A*02:01‐restricted epitopes from HBV envelope, polymerase, and core antigens were engineered. The ability of ImmTAV‐Env to activate and redirect polyclonal T cells toward cells containing integrated HBV and cells infected with HBV was...
The recognition of antigenic peptide-MHC (pMHC) molecules by T-cell receptors (TCR) initiates the T-cell mediated immune response. Structural characterization is key for understanding the specificity of TCR-pMHC interactions and informing the development
The Tec-family kinase Itk plays an important role during T-cell activation and function, and controls also conventional versus innate-like T-cell development. We have characterized the transcriptome of Itk-deficient CD3+ T-cells, including CD4+ and CD8+ subsets, using Affymetrix microarrays. Result...
The increase in T cells and the decrease in NK and CD3CD56NKT cells suggest a shift from innate to adaptive hepatic immunity in the liver graft.Highlights? We investigated the distribution of T, NK and NKT cells in transplanted livers. ? Cells were analyzed in liver core biopsies using ...
Cibisatamab is a bispecific antibody-based construct targeting carcinoembryonic antigen (CEA) on tumour cells and CD3 epsilon chain as a T-cell engager. Here we evaluated cibisatamab for advanced CEA-positive solid tumours in two open-label Phase 1 dose-
Company Unveils EVOLVE-105 Program, A Best-in-Class CD20xCD3 Multispecific Antibody Designed to Concurrently Drive CD2 Costimulation to Improve the Treatment of B cell Malignancies Expanding Portfolio of First-in-Category Costimulatory T Cell Engagers Highlights Ability of Modular EVOLVE Platform to Target...
首先,CAR-T、TCR-T、NK(自然杀伤细胞)均属体细胞,应适用有关体细胞的一系列法律法规和指导原则。 按药品注册进行 CAR-T细胞、TCR-T细胞、NK细胞均属于免疫细胞,其治疗产品适用免疫细胞治疗产品注册上市的指导原则。例如《免疫细胞治疗产品药学研...
Drop deprecated contourgl and area traces as well as deprecated legacy pre-scatterpolar polar-related attributes bar.t, bar.r, scatter.t, scatter.r, layout.radialaxis, layout.angularaxis and gd.framework [#5399, #5408, #5409, #5398, #5438] Stop overwriting the "latest" bundles on CDN, ...