Enhanced B cell activity, particularly memory B cells have gained interest in evaluating response during therapies with biologics. CD27-IgD- double-negative (DN) B cells lacking the conventional memory marker CD27 are reported to be part of the memory compartment, however, only scarce data is ...
Inflammation Research (2022) 71:131–140 https://doi.org/10.1007/s00011-021-01525-3 ORIGINAL RESEARCH ARTICLE Inflammation Research Severity of SARS‑CoV‑2 infection is linked to double‑negative (CD27− IgD−) B cell subset numbers Rodrigo Cervantes‑Díaz1,2 ·...
CD27is expressed on lymphocytes andhematopoietic stem cellsand binds to its only known ligand CD70 on activated lymphocytes,NK cells, and dendritic cells [105–107]. CD27-CD70 signaling has been shown to activate stem cell gene signatures inAML cellsin vitro and aberrant expression of CD27 ha...
falciparum transmission on development of B cell subsets, PBMCs were stained with CD19, IgD and CD27 mABs to discriminate naive (IgD+CD27-) from three memory B cell subsets; classical (IgD-CD27+), non class-switched (IgD+CD27+) and IgD-CD27-. This latter subset is a heterogeneous ...
1 Depending on the disease, the phenotypic markers and in vitro stimulation used, different B-cell subsets are enriched in Bregs, including CD24hiCD27+ B cells7 and CD24hiCD38hi transitional B cells.21,24 GC reactions may play a major role in the pathogenesis of cGVHD in mice.25, 26,...
gupnp-igd-0.2.5-2.el7.src.rpm SHA-256: 786b73e91f6ec83cd6787406ca56df16b5f54ce84f50f9a50d7613b087a349b8 gvfs-1.36.2-1.el7.src.rpm SHA-256: e0a1747d59bd3154ce3f0c3d62ba21a92e5b5d83190f62831ef5f7a8ef468119 harfbuzz-1.7.5-2.el7.src.rpm SHA-256: 7402dd065996618aaecd2f9e84a55...
In normal lymphoid development, the expression of CD27 and CD70 on B cells is finely regulated. This important receptor-ligand pair regulates proliferation and differentiation of memory B-cells towards the terminally differentiated plasma cell and to our knowledge, this is the first report showing ...
B cell subsets were classified as either nave (CD27—IgD+), class-switched memory (CD27+IgD—), unswitched memory (CD27+IgD+) or double negative (DN)(CD27—IgD—). DN B cells were further characterised into DN1 (CXCR5+CD21+) and DN2 (CXCR5—CD21—) subsets. In vitro co-...
In addition, activated B cells identified manually exhibited a cell surface phenotype (CD11c+CXCR3+CXCR5−CD38−IgD+/−) similar to that observed with unsupervised clustering (Fig. 3A, Supplementary Fig. 3). Using manual gating, we confirmed the increase in C D21−CD27− ...
The antibodies of the invention can interfere with CD27:CD70 ligation, inhibit both T-cell effector functions and B-cell differentiation to plasma cells in cell culture and thus may be beneficial for treatment of immune-mediated diseases including, but not limited to, rheumatoid arthritis, systemic...