IL-12 Induces Human CD4+CD45RA-CD25hiCD127low/neg Regulatory T Cells to Secrete IFN gamma, and IL-10 and Acquire a Non-regulatory Effector PhenotypeDominguez-VillarM.HaflerD.Baecher-AllanC.ingentaconnectClinical Immunology San Diego Academic Press...
Reduced CD4+ CD25(++) CD45RA(-) Foxp3(hi) activated regulatory T cells and its association with acute rejection in patients with kidney transplantationRegulatory T cellActivated TregsEffector T cellKidney transplantationAcute rejectionBackground: It was found that regulatory T cells (Tregs) ...
IL-12 Induces Human CD4+CD45RA-CD25hiCD127low/neg Regulatory T Cells to Secrete IFN gamma, and IL-10 and Acquire a Non-regulatory Effector Phenotypedoi:10.1016/j.clim.2010.03.400MargaritaDominguez-VillarandDavidHaflerandClareBaecher-Allan
By using flow cytometer, the frequencies of CD4 + CD25 ++ CD45RA - Foxp3 hi activated Tregs (aTregs), CD4 + CD25 + CD45RA + Foxp3 lo resting Tregs (rTregs), CD4 + CD25 + CD45RA - Foxp3 lo non-suppressive T cells, CD4 + CD25 + Foxp3 - cells Teff, and total Tregs were ...
Antigen specific T regulatory cells (Treg) are often CD4(+)CD25(+)FoxP3(+) T cells, with a phenotype similar to natural Treg (nTreg). It is assumed that nTreg cannot develop into an antigen specific Treg as repeated culture with IL-2 and a specific antigen does not increase the ...