Antigen specific T regulatory cells (Treg) are often CD4(+)CD25(+)FoxP3(+) T cells, with a phenotype similar to natural Treg (nTreg). It is assumed that nTreg cannot develop into an antigen specific Treg as repeated culture with IL-2 and a specific antigen does not increase the ...
3,*, Fengfan Yang1,3, Xin Zhang1,3, Qing Han1,3, Zhi-Nan Chen2,3 & Ping Zhu1,3 Forkhead box P3 (FoxP3)-positive regulatory T cells (Tregs) play a pivotal role in the preservation of self-tolerance, and Treg dysfunction has been implicated in many autoimmune diseases. ...
4,5 However, both CD8 and CD4 T cells are capable of mediating GVHD. Moreover, attempting to reduce GVHD by limiting perforin and FasL function has not prevented GVHD, and CD8 T cells would likely have detrimental effects on engraftment and the capacity for graft-versus-leukemia (GVL) ...
Multiple sclerosis (MS) is an immune-mediated disease in which autoimmune T conventional (Tconv) cells break the blood–brain barrier and destroy neurons of the central nervous system. It is hypothesized that CD4+CD25highCD127−FoxP3+T regulatory (Treg) cells may inhibit this destruction throug...
Introduction CD4+CD25+/highCD127low/- regulatory T cells (Tregs) play a crucial role in maintaining peripheral tolerance. Data about the frequency of Tregs in rheumatoid arthritis (RA) are contradictory and based on the analysis of peripheral blood (PB) and synovial fluid (SF). Because Tregs ...
In this study, the frequency and function of CD4 + CD25 + CD45RA + regulatory T cells (Treg) and intracellular IL‐2 signalling molecules in patients with ... Sheikh VidaZamani AlirezaMahabadi‐Ashtiyani ElhamTarokhian HaniehBorzouei ShivaAlahgholi‐Hajibehzad Mahdi - 《Scandinavian Journal of...
No significant difference was found in CD127-CD25- subsets distribution (p = 0.0759) (Figure 1B). CD4+T cells can be divided into four different subsets depending on expression level of CD45RA and CD27: naïve cells (CD27+CD45RA+), central memory cells (CD27+CD45RA-), effector ...
The percentages of peripheral blood CD4+CD25hiFoxp3hi (Figure 1C) and CD4+CD25hiCD127lo (Figure 1D) Treg populations did not increase after the administration of G-CSF alone. In contrast, Treg percentages were increased after GM-CSF alone, with higher percentages of Treg maintained after an...
CD4+T cells can be divided into five populations using CD45RA and either Foxp3 or CD25 expression37,43(Fig.1A). Population I mainly contains thymus derived resting Treg that express CD45RA, CD25 and Foxp3 and is large at birth but decreases with age42. Population II identifies activated ...
未治疗HIV/AIDS患者CD4CD25Foxp3CD45RO记忆性调节性 T细胞百分率与CD4T细胞显著负相关(【:一0.690,P<0.001),与病毒载量明显正相关(r=0.401,P:0.002),与CD4 HLA.DR、CD8HLA.DR、CD8CD38细胞显著正相关(P<0.05),与CD4CD95 、CD8CD95T细胞水平显著正相关(P <0.05)。结论:HIV感染者CIMCD25Foxp3CIM5RO记忆性...