To understand the contribution of mononuclear phagocytes (MNP), which include monocyte-derived intestinal macrophages, to the pathogenesis of inflammatory bowel disease (IBD), it is necessary to identify functi
unlabeled D10CM revealed a reduction of approximately 85%, confirming specific tracer binding.#Al[18F]F-NOTA-D10CM PET detects overexpression of CD206 after ischemic myocardial injury, and may be a suitable biomarker for detecting M2-type macrophages associated with the inflammatory process post-MI...
Figure 2. Analysis of inflammatory cells infiltrating into renal tissue. A: Immunostaining of CD68+ macrophages infiltrating the kidney in mice exposed to nephrotoxic serum. B and C: Immunostaining of inflammatory leukocytes infiltrating the kidney in NTS-GN mice treated with phosphate-buffered saline...
Antineutrophil Cytoplasmic Antibodies (ANCA) associated glomerulonephritis (AGN) is a group of autoimmune diseases and mono-macrophages are involved in its glomerular injuries. In this study, we aim to investigate the role of CD206+ mono-macrophages in A
These activated monocytes would then differ- entiate to CD206+ macrophages which is a subtype of alternatively activated macrophages that express pro- inflammatory cytokines and play important roles in many kidney diseases and autoimmune disorders [15]. Li and colleagues showed in their study ...
Objective-Insulin resistance and other features of the metabolic syndrome have been causally linked to adipose tissue macrophages (ATMs) in mice with diet-induced obesity. We aimed to characterize macrophage phenotype and function in human subcutaneous and omental adipose tissue in relation to insulin ...
A previous report showed that the developing choroid plexus permits the entry of macrophages into the ventricle by secreting inflammatory molecules into the cerebrospinal fluid during maternal inflammatory states.30 Thus, our analysis at E12.5 focused on the roof plate, which is known to give rise ...
Phagosome maturation in polarized macrophages. J. Leukoc. Biol. 96, 729–738 (2014). 26. Chistiakov, D. A. et al. Macrophage phenotypic plasticity in atherosclerosis: The associated features and the peculiarities of the expression of inflammatory genes. Int. J. Cardiol. 184, 436–445 (2015...
Depletion of alveolar macrophages can lead to an exacerbated inflammatory process and it is recognized that the main mechanism is the lacking of control of this process [30]. Figure 5 (a) Open in figure viewerPowerPoint Increased CD206+ cells were found in influenza A (H1N1)pdm09. ...
7). The recruitment and polarization of CD163+ macrophages, triggered by M-CSF signaling, is an important driver of the acute inflammatory process in the glomerulus that leads to crescent formation. On the other hand, the high expression of GM-CSF in the tubular cell polarized CD206+ ...