B cells that expressed CD20 were CD20bright and constituted an average of 9.2 卤 3.3% of adult PBL. Meanwhile, T cells that expressed CD20 were CD20dim and represented 2.4 卤 1.5% of the PBL. This population may have been overlooked in previous studies due to the low level of CD20 ...
Further examination of the splenic CD8+ T cells revealed increased intracellular Granzyme B expression after Bdep therapy (supplemental Figure 5). This may be related to how CD20low 4-1BBL+ B-regulatory cells regulate Granzyme B expression in CD8+ T cells.22,23 Although Granzyme B expression ...
The therapeutic potential of anti-CD20: “What do B-cells do?” An anti-CD20 chimeric mAb (rituximab) has been FDA approved for treatment of B-cell lymphomas since 1997. Rituximab also depletes normal B-cells by ... Robert Eisenberg and R. John Looney - 《Clinical Immunology》 被引量:...
CD20 expression on B cells is synchronous with the expression of surface IgM and it regulates transmembrane calcium conductance, cell cycle progression and B-cell proliferation. CD20 is also associated with lipid rafts, but the intensity of this association depends on extracellular triggering, employing...
and at low levels on a T cell subset. CD20 is heavily phosphorylated on activated B cells and malignant B cells. Homo-oligomeric complexes of CD20 are thought to form Ca2+ conductive ion channels in the plasma membrane of B cells. The CD20 molecule is involved in B-cell activation and is...
该Purified Anti-Human CD20 Monoclonal Antibody. CD20 is a 33-37 kD, four transmembrane spanning protein, also known as B1 and Bp35. CD20 is expressed on pre-B-cells, resting and activated B cells (not plasma cells), some follicular dendritic cells, and at low levels on a T cell subset...
CD20 is a cell surface 33-37 (depending on the degree of phosphorylation) kDa non-glycosylated surface phosphoprotein expressed on mature and most malignant B cells, but not stem cells or plasma cells (low number of the CD20 has been also detected on a subpopulation of T lymphocytes and it ...
CD20 is expressed early during pre- B cell development, presumably just before the expression of cytoplasmic μ- chains, and it persists until plasma cell differentiation. A small subset of T cells expresses low levels of CD20. CD20 is expressed in acute lymphoblastic leukaemia, B- cell chronic...
In addition, Anti-B1 Antibody showed direct induction of apoptosis in all B-cell lines tested. In general, crosslinking Anti-B1 Antibody with a goat anti-mouse Ig did not further enhance the percentage of cells undergoing apoptosis. Importantly, a F(ab') 2 fragment of Anti-B1 Antibody ...
and at low levels on a T cell subset. CD20 is heavily phosphorylatedon activated B cells and malignant B cells. Homo-oligomeric complexes of CD20 are thoughtto form Ca conductive ion channels in the plasma membrane of B cells. The CD20 moleculeis involved in B-cell activation and is associa...