Ginaldi L, De Martinis M, Matutes E, Farahat N, Morilla R, Catovsky D. Levels of expression of CD19 and CD20 in chronic B cell leukaemias. J Clin Pathol. 1998; 51 (5):364–369. doi: 10.1136/jcp.51.5.364. [ Cross Ref ]
10 patients had positive expression of both CD19 and CD20 as confirmed by immunohistochemistry. Safety and adverse events Eleven patients received CD19/20 CAR-T cell products. Five patients (45%) developed CRS with a median onset of 4 days after infusion (range 1–16) and a median duration...
Transduction with parallel CAR19/20 resulted in dual expression of CD19 and CD20 in patients’ T cells (Figure 5(b)). Similar to single and tandem CAR T-cells, parallel CAR19/20 T-cells dose dependently induced cell death of patients’ leukemia cells, achieving almost complete specific ...
Specifically, CD20 expression at diagnosis predicts relapse in adult patients, such that CD20-directed antibody therapy is now being incorporated into front-line therapy for adult BL-ALL [25, 26]. Based on these observations, we hypothesized that simultaneous targeting of CD20 and CD22 could ...
ENPP3CD203c/ENPP-3 protein, recombinant CTLA4CTLA-4 protein, recombinant CD3ECD3 epsilon/CD3e protein, recombinant SLAMF1SLAM/CD150 protein, recombinant CLEC4MDC-SIGNR/CD299 protein, recombinant CD74CD74 protein, recombinant PTPRCCD45 protein, recombinant ...
Expression of the scFvs was induced with 0.2 mM of IPTG at 22 °C when OD600 reached 0.8. Cells were harvested by centrifugation after 16 h of induction. For extraction of HD37-C from the periplasmic space of E. coli, cells were incubated with the periplasmic extraction buffer (100 mM ...
26.根据权利要求7、12、16或17所述的双特异性抗体或抗原结合片段,其中所述双特异 性抗体或抗原结合片段与CD3、CD4、CD8、CD20、CD19、CD21、CD23、CD46、CD80、HLA‑DR、CD74、 CD19、CD14、CD15、CD16、CD123、TCRγ/δ、NKp46、KIR或小分子DOTA半抗原结合。 27.一种用于治疗有需要的受试者的CD19...
②116 例检测了骨髓瘤免疫表型的患者中,骨髓瘤细胞表面出现 CD19,CD20,CD56 和 CD117 等表达,其中 CD56 阳性者 61. 21% (71/116),CD56 阴性者 38. 79% (45/116);CD56 阳性者无进展生存期和总生存期较阴性者明显延长(PFS:37. 50 月 vs 18. 40 月,P =0. 036;OS:53. 00 月vs 31. 00 月,...
The bottom right panel shows CD19 expression on CD138+CD38+ PCs (red) and CD20+CD19+ cells (blue); the green histogram represents CD138+CD38+ cells with fluorescence-minus-one (CD19) staining. Representative data from 7 donors are shown. The “dump” channel contains stains for viability...
(SPPL3) in malignant B cells as a potent regulator of resistance to CAR therapy. Loss of SPPL3 results in hyperglycosylation of CD19, an alteration that directly inhibits CAR T cell effector function and suppresses anti-tumor cytotoxicity. Alternatively, over-expression of SPPL3 drives loss of...