他认为新合成的蛋白质具有内源性信号,即信号肽(Signal peptide,SP)。信号肽是一段存在于前体蛋白N‑端的短肽链,能够调节前体蛋白的折叠和转移过程。研究表明,在原核系统中,信号肽附着后,外源基因能够在原核表达系统中成功表达并分泌,如芽孢杆菌、乳酸杆菌、L型细菌、大肠杆菌等。除此之外,信号肽还广泛应用于真核...
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Genes The human CD19 gene is located on chromosome 16p11.2, spans over 7.5 kb genomic DNA, has 15 exons and codes for a 556 amino acid protein including the signal peptide. In one patient, a homozygous insertion of one base pair in exon 6 has been detected, whereas the ot ......
Here we identify expression of the Golgi-resident intramembrane protease Signal peptide peptidase-like 3 (SPPL3) in malignant B cells as a potent regulator of resistance to CAR therapy. Loss of SPPL3 results in hyperglycosylation of CD19, an alteration that directly inhibits CAR T cell effector...
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a A tricistronic vector was designed with self-cleaving 2A peptides, enabling trivalent protein expression of CD19/20/22-directed CARs on T-cells. b Design of CAR transgenes. Each CAR endo-domain contains a CD8α hinge and transmembrane region followed by downstream 4-1BB and CD3ζ intracel...
Genes The human CD19 gene is located on chromosome 16p11.2, spans over 7.5 kb genomic DNA, has 15 exons and codes for a 556 amino acid protein including the signal peptide. In one patient, a homozygous insertion of one base pair in exon 6 has been detected, whereas the ot ... 展开 ...
(T cell receptor) on T cells and the MHC-peptide complex on antigen-presenting cells [4-5]. Because of its short cytoplasmic tail, the TCR lacks the ability to signal and requires non-covalent association with the CD3. Upon antigen recognition, the TCR/CD3 complex on T cells triggers ...
Since 1st Gen CARs lack a co-activating signal, the co-stimulatory 4-1BB unit integrated in the CCR construct should act as a switch that, upon binding to one of its ligands, provides the signal to fully activate the CD19-redirected CAR/CCR T cells. We thereby intend to increase the ...