Percent bone marrow (%BM) irradiated was calculated by estimating skeletal BM distribution. Progression-free survival (PFS), disease-specific survival (DSS), and overall survival (OS) were modeled via Kaplan-Meier. RESULTS: Fifty-one patients received bRT, of which 13 (25.5%) had bulky disease...
Percent specific lysis was calculated using the control of target cells without effectors. For long-term killing assays, CAR T cells were combined with target cancer cells at an E:T ratio of 0.125:1 or 0.0625:1, and co-cultures were evaluated for absolute counts of T cells and cancer ...
memoryBcellsinperipheralbloodofthepatientswithRAweresignificantlydecreased,whilethepercenta gesofnaiveBcellswereincreased(P<0.05).Thepercentagesofplasmablastsinthepatientswithactive RAweresignificantlyincreasedascomparedwiththoseofhealthysubjectsandthepatientswithinactiveRA (P<0.05).(2)Thepercentagesofplasmablastsin...
Data are presented as peak response normalized to the baseline, and then expressed as percent increase over the baseline, ±SD. ∗, p ≤ .05 compared with N; #, compared with A-P; ∗∗, compared with A-BMDMC; τ, compared with A-CD11b. Abbreviations: A, Aspergillus hyphal ...
B lymphocytes proliferated when approximately 100 antigen receptors per cell, 0.03 percent of the total, were coligated with CD19. The B cell resolves its dilemma by having an accessory protein that enables activation when few antigen receptors are occupied....
d, Logistic regression models for predicting response at 6 months based on either percent of CAR TReg cells (top, n = 28), or whether pre-LD LDH levels were above normal (bottom, n = 29). Models were fit using all available data from the discovery cohort, with parameters ...
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Leukemia & Lymphoma Society. Available at:https://www.lls.org/research/acute-lymphoblastic-leukemia-all#:~:text=B%2DALL%20is%20more%20common,about%2075%20percent%20of%20cases. Accessed onFebruary 8, 2024....
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b The ratio of CD19 and CD20 antigen binding by each tandem-CAR is expressed as the ratio of percent cells bound by CD20 biotin vs CD19 Fc. The average + SD of three separate experiments using three donors is shown, **p < 0.01 Full size image To compare differences in ...