Representative histograms showing the surface expression of IgM, IgD, CD5, CD10, CD27, and CD1d of CD19+CD24hiCD38hi, CD19+CD24+CD38−, and CD19+CD24intCD38int B cell subsets. Results are representative of 14 different healthy controls. (B) CD1d and CD5 expression on CD19+ B ...
B-1 cells are the predominant B cell subpopulation found in the peritoneal cavity of adult mice and are thought to represent either a distinct subset or lineage of B cells (31, 33, 38). CD21 appears on the surface of human and mouse B cells at about the same time as IgD (Figure 1...
重链恒定区可以是IgGl、IgG2、IgG3、IgG4、IgA、IgE、IgM或IgD恒定区,但是最优选的是IgGl或IgG4恒定区。对于Fab片段重链基因,编码VH的DNA可以与只编码重链CHI恒定区的另外一种DNA分子有效连接。通过将编码Vl的DNA与编码轻链恒定区CL的另外一种DNA分子有效连接,可以将分离的编码VL区的DNA转化为全长轻链基因(...
Specific B-cell subsets play a key role in antiviral humoral immunity. To investigate whether SARS-CoV-2 infection affects the B-cell immune phenotype, we first examined the naive B cells (CD27−IgD+), atypical (CD27−IgD−), switched (CD27+IgD−) and unswitched (CD27+IgD+) memo...
例如,针对成熟B细胞及其恶性对应物的特异性CD20细胞表面分子的嵌合或放射性标记的单克隆抗体(mAb)疗法能够在体内有效治疗非霍奇金淋巴瘤(Tedder等,/m/mmo/.7bcfoj15:450-454(1994);Press等,i/em^o/ogy:221-240(2001);Kaminski等,iV.J.Med329:459-465(1993);Weiner,Sem/".0"co/.26:43-51(1999);On...
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Furthermore, the addition of MZ to the G-CSF-based mobilization regimen exerted no measurable effect on the relative frequency of T-cell and B-cell subsets (data not shown). Previous studies showed that G-CSF skews T-cell function towards a regulatory profile, both in mice and in humans ...
抗CD19组合疗法.pdf,本公开涉及抗CD19抗体和R‑CHOP或抗CD19抗体、来那度胺与R‑CHOP的治疗组合,其用于治疗弥漫性大B细胞淋巴瘤。本公开还涉及抗CD19抗体、来那度胺与利妥昔单抗的治疗组合,其用于治疗非霍奇金氏淋巴瘤、慢性淋巴细胞性白血病或急性淋巴母细胞性白血病
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Callard, Robin E., et al., “CD19 Regulation of Human B Cell Responses, B Cell Proliferation and Antibody Secretion Are Inhibited or Enhanced by Ligation of the CD19 Surface Glycoprotein Depending on the Stimulating Signal Used”, The Journal of Immunology, May 15, 1992, pp. 2983-2987, vo...