方法:采用流式细胞术检测TAO患者和健康对照组CD19^(+)CD27^(+)IgD^(+)B细胞比例,分析TAO患者CD19^(+)CD27^(+)IgD^(+)B细胞比例与健康对照组的差异,并分析CD19^(+)CD27^(+)IgD^(+)B细胞比例与TAO疾病活动度之间的相关性。结果:TAO患者CD19^(+)CD27^(+)IgD^(+)B细胞比例明显低于健康对照(P<...
IgD 三个分化抗原将 B 细胞亚群分为静止 B 细胞 (CD19 + IgD + CD27 - )、非转换记忆 B 细胞( CD19 + IgD + CD27 + )、 经典转换记忆 B 细胞( CD19 + IgD - CD27 + ) 以及双阴性 B 细胞( CD19 + IgD - CD27 - )。 Morbach等 [8] 在Barbara等 [7] 研究的基础上加入 CD24、CD38...
CD21 appears on the surface of human and mouse B cells at about the same time as IgD (Figure 1B) and is also expressed by follicular dendritic cells (52, 84). CD35 appears early in human B cell development (Tedder et al. 1983), but is not a component of the hCD19 complex. ...
The patient had a small number of IgD(-) CD27(+) memory B cells, in which somatic mutation were detected. His B cells showed substantial proliferation upon stimulation, but reduced IgG and IgA production in vitro. These findings extend the mutation spectrum of the CD19 deficiency to four, ...
6.根据权利要求5所述的三功能分子,其特征在于,所述连接片段1和连接片段2选自以G4S为单位的连接片段或免疫球蛋白IgD的铰链区片段。 7.根据权利要求6所述的三功能分子,其特征在于,以G4S为单位的连接片段的氨基酸序列如SEQ ID NO.23、SEQ ID NO.25、SEQ ID NO.27之任一所示;免疫球蛋白IgD的铰链区片段的氨基...
SARS-CoV-2 infection alters the immune phenotype and function of B cells and reduces CD19 expression on B cells from recovered COVID-19 patients. Flow cytometry analysis of the frequencies of naive B cells (naive, CD19+IgD+CD27−), class-switched B cells (switched, CD19+IgD−CD27+)...
在本研究中,研究者纳入了 18~70 岁 TE NDMM 患者,符合以下 1 个及以上高危因素方可入组:①R-ISS Ⅱ 期或 Ⅲ期;②del17p,t(4;14),t(14;16),或1q21 拷贝数 ≥ 4 ;③髓外病变(EM);④IgD 或 IgE 亚型;⑤LDH>正...
CD19+CD24hiCD38− B cells were CD5−CD10−CD27+CD1d+ and can have either an IgM+IgD+ or IgM−IgD− phenotype (Figure 1A). Interestingly, the majority of the CD19+CD5+CD1dhiB cells (71%), previously reported to be regulatory in experimental models of inflammation (Matsushita ...
对CAR T治疗前和治疗后的B细胞的免疫表型分析显示,重建的B细胞主要是CD21+CD27-幼稚细胞,而在SLE中扩增的CD11c+CD21lo激活的记忆B细胞并不存在。且治疗前后的B细胞受体测序数据显示,从基线的类别转换IgG和IgA重链转变为非类编转换...
(d)选自IgG1、IgD、IgG4和IgG 4 Fc区的免疫球蛋白。 19.如权利要求9所述的组合物,其中所述跨膜结构域包含选自由SEQ ID NO:375-425和897-907中任一者组成的组的氨基酸序列。 20.如权利要求9所述的组合物,其中所述CAR还包含 (e)接近所述跨膜结构域的铰链区,所述铰链区包含选自由SEQ ID NO:426-504中...