[4] Kansal, R. et al. Sustained B cell depletion by CD19-targeted CAR T cells is a highly efective treatment for murine lupus. Sci. Transl. Med. 11, eaav1648 (2019). [5] Li, W., Titov, A. A. & Morel, L. An update on lupus...
这些患者在环磷酰胺和氟达拉滨预处理后接受单剂量的CD19 CAR-T细胞治疗,接受CAR-T疗法后中位随访时间为15个月(4~29个月)。 然后,每3个月通过系统性红斑狼疮缓解定义(DORIS)标准、美国风湿病学会/欧洲抗风湿病联盟(ACR-EULAR)的主要临床...
相关研究结果发表在2021年8月5日的NEJM期刊上,论文标题为“CD19-Targeted CAR T Cells in Refractory Systemic Lupus Erythematosus”。 系统性红斑狼疮是一种自身免疫性疾病,可导致全身器官损伤。论文通讯作者、埃朗根-纽伦堡大学的Georg Schett博士说,这名女性是世界上第一个用CAR-T细胞治疗的狼疮患者。这意味着在这...
相关研究结果发表在2021年8月5日的NEJM期刊上,论文标题为“CD19-Targeted CAR T Cells in Refractory Systemic Lupus Erythematosus”。 系统性红斑狼疮是一种自身免疫性疾病,可导致全身器官损伤。论文通讯作者、埃朗根-纽伦堡大学的Georg Schett博士说,这名女性是世界上第一个用CAR-T细胞治疗的狼疮患者。这意味着在这...
Author Correction: Anti-CD19 CAR T cell therapy for refractory systemic lupus erythematosusdoi:10.1038/s41591-022-02091-9Nature Publishing Group USNature Medicine
CD19 CAR T-Cell Therapy in Autoimmune Disease — A Case Series with Follow-up.pdf Abstract 抽象的 BACKGROUND 背景 Treatment for autoimmune diseases such as systemic lupus erythematosus (SLE), idiopathic inflammatory myositis, and systemic sclerosis often involves long-term immune suppression. Resetting...
Therapeutic efficacy of anti-CD19 CAR-T cells in a mouse model of systemic lupus erythematosus Article29 May 2020 IL-2 immunotherapy for targeting regulatory T cells in autoimmunity ArticleOpen access23 September 2023 Regulatory T cells function in established systemic inflammation and reverse fatal au...
Abstract Dysregulated B-cell activation plays pivotal roles in systemic lupus erythematosus (SLE), which makes B-cell depletion a potential strategy for SLE treatment. The clinical success of anti-CD19 CAR-T cells in treating B-cell malignancies has attracted the attention of researchers. In this...
Faculty Opinions recommendation of Sustained B cell depletion by CD19-targeted CAR T cells is a highly effective treatment for murine lupus. J Radhakrishnan,EC Morales - Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature 被引量: 0发表: 2019年 Increased Frequency of Pre-...
Anti-CD19 CAR Tcells were among the last decade's scientific breakthroughs, achieving remarkable remissions in patients with B cell leukemias and lymphomas. Now, the engineered cell therapies are traversing disease indications into autoimmunity and resolving disease symptoms in patients with systemic lup...