CD19 CAR T-Cell Therapy in Autoimmune Disease - A Case Series with Follow-up. N Engl J Med. 2024 Feb 22;390(8):687-700. 关于BioBro大师兄 BioBro大师兄是一个聚焦生物医药领域产学研的共享平台,包括专业交流以及干货内容和供应链信息分享,持续关注细胞治疗、基因治疗、干细胞药物、抗体药物等领域的前...
2024年10月4日,Nature在其官网头条位置,报道了一项由中国科学家团队在Cell杂志上发表的研究成果-World-first therapy using donor cells sends autoimmune diseases into remission(世界上第一个使用供体细胞的疗法可以缓解自身免疫性疾病)。 文献解读 文章:Allogeneic CD19-targeted CAR-T therapy in patients with seve...
CD19 CAR-T cell therapy: a new dawn for autoimmune rheumatic diseases? - PubMed CAR-T cell therapy embarks on autoimmune disease | Bone Marrow Transplantation Frontiers | CD19 CAR-T cell therapy: a new dawn for autoimmune rheumatic diseases? 天气凉了,“手指变色”要小心雷诺现象 自身免疫性疾...
近日,国际顶级期刊NEJM(The New England Journal of Medicine)发表了一篇题为“CD19 CAR T-Cell Therapy in Autoimmune Disease-A Case Series with Follow-up.”的文章。来自德国埃尔兰根大学医院研究人员使用 CAR-T细胞疗法治疗15名患有严重...
CAR-T cell therapyNK cellsNKG2AFcγ receptorThe high potential of CD19.CAR-T cells to treat autoimmune diseases such as Systemic Sclerosis (SSc) supposedly relies on the disappearance of autoantibodies. Here we investigated effects of CAR-T cells on the innate immune system which is an ...
Chimeric antigen receptor T cell therapy for autoimmune disease 2024, Nature Reviews Immunology Advancements and challenges in CAR T cell therapy in autoimmune diseases 2024, Nature Reviews Rheumatology Successful use of anti-CD19 CAR T cells in severe treatment-refractory stiff-person syndrome 2024, ...
A unique population of IgG-expressing plasma cells lacking CD19 is enriched in human bone marrow Blood (2015) F. Müller et al. CD19 CAR T-Cell Therapy in Autoimmune Disease — A Case Series with Follow-up N. Engl. J. Med. (2024) S.M. Jung et al. Targeted Immunotherapy for Autoimm...
Munoz L, Gerlach RG, Schäfer S, Grieshaber-Bouyer R, Korganow AS, Farge-Bancel D, Mougiakakos D, Bozec A, Winkler T, Krönke G, Mackensen A, Schett G. CD19 CAR T-Cell Therapy in Autoimmune Disease – A Case Series with Follow-up. N Engl J Med. 2024 Feb 22;390(8):687-...
其他CD19 自身免疫病CAR-T: 自2022年Carl June在Cell上发表题为"CAR T therapy extends its reach to autoimmune diseases"的论文起,CD19 CAR-T细胞拦截B细胞驱动的自身免疫性疾病的概念正在逐渐得到验证。 其中一方面,单纯通过靶向CD20造成异常的B细胞耗竭可能还不够,因为B细胞前体(在SSc等适应症中特异性扩增)和...
总的来说,CAR-T细胞疗法在风湿性自身免疫性疾病患者中的安全性和有效性不受影响,此外还对风湿病取得了更好的生化控制。 参考文献 Wang JS,et al. CD19-targeted chimeric antigen receptor T-cell therapy in patients with concurr...