CAR T-cell enumeration was assessed by MFC. Serum cytokine concentrations (20 analytes) were measured by Luminex assay. Univariate associations between duration of response (DOR) and patient, disease, CAR T-cell manufacturing, and treatment-related variables were estimated using Cox regression (50+ ...
Czerkinsky CC, Nilsson LA, Nygren H, Ouchterlony O, Tarkowski A . A solid-phase enzyme-linked immunospot (ELISPOT) assay for enumeration of specific antibody-secreting cells.J Immunol Meth1983;65: 109–121. ArticleCASGoogle Scholar Fayette J, Dubois B, Vandenabeele S, Bridon J-M, Vanber...
f, Enumeration of various immune cell populations in the blood of Patient-10. The frequency of each population is listed in a separate column that corresponds to its phenotypic marker. Extended Data Fig. 3 Clonal composition of CAR T cells from Patient-10 and other subjects treated with CTL...
Figure 1. Emergence of CD19−myeloid phenotype blasts after effective CD19 CAR-T-cell therapy for CD19+ MLL-rearranged B-ALL. (A-E) Data from the patient in case 1. (F-H) Data from the patient in case 2. (A) The percentage of CD19-specific CAR-T cells in CD3+ T cells (ope...