Effect of Antibody BindingADCP, cytokine releaseADCC, ADCP, vaccinal effectInhibits ADCC, ADCP, B cell activationEnhances ADCC, ADCP, B cell activationADCC, ADCPDecoy receptor that inhibits ADCP 抗体依赖性细胞介导的细胞毒性(ADCC)是一种有效的细胞毒性机制。NK细胞通CD16A (FcγRIIIA)识别细胞结合的抗...
Signal transduction during NK cell activation via CD16: G proteins regulate inositol phosphate generation and ADCC activity.Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical...
5.1NK cell activation via CD16 The Fc receptorCD16is the only receptor that can activate resting NK cells when stimulated in isolation. CD16 mediates ADCC, which is dependent on antibodies produced by B cells. Therefore, the unwanted activation of resting NK cells through CD16 is still under...
glycosylphosphatidylinositol(GPI)-anchored protein. Its extracellular domain is over 95% homologous to that of CD16a,and it is expressed specifically on neutrophils. CD16 binds aggregated IgG or IgG-antigencomplex which functions in NK cell activation, phagocytosis, and antibody-dependent cellmediated ...
Sivori S., Parolini S., Falco M., Marcenaro E., Biassoni R., Bottino C., et al. (2000). 2B4 functions as a co-receptor in human NK cell activation. European Journal of Immunology, 30(3), 787-793. Bryceson Y.T., Fauriat C., Nunes J.M., Wood S.M., Bj?rkstr?m N.K....
Its extracellular domain is over 95% homologous to that of CD16a, and it is expressed specifically on neutrophils. CD16 binds aggregated IgG or IgG-antigen complex which functions in NK cell activation, phagocytosis, and antibody-dependent cell-mediated cytotoxicity (ADCC)....
In subsequent in vitro studies with normal fresh NK cells, it was demonstrated that IgG-containing RF complexes from RA patients induced a modulation of FCRIII structure from the NK cell surface, a decrease in NK activity, and a complete loss of ADCC. When purified RF was incubated with NK...
CD16, the low affinity receptor for monomeric IgG (Fc纬RIIIA), is a well characterized activation molecule on NK cells. In this study we investigated the role of CD16 in NK cell-mediated regulation of immunoglobulin production. Cocultures of the CD16+ human NK clone CNK6 and highly ...
Furthermore, CD7+CD56negCD16+ NK cells have significantly increased expression of CD95, a marker of NK cell activation. Conclusions Taken together, CD7+CD56negCD16+ NK cells are activated, mature NK cells that may have recently engaged target cells. 展开 ...
Importantly, CD16 cell-surface expression is downmodulated following NK cell activation and, in particular, exposure to stimulatory cytokines (IL-2 or IL-15), likely owing to the action of matrix metalloproteinases (MMPs). In this ... P Galajda - International School of Mathematics " G Stamp...