CD147在癌症中所扮演的角色令人饶有兴趣。它既非抑癌基因/看门基因(gatekeeper gene),似乎也非原癌基因,更非看护基因(caretaker gene)。现实地说,CD147对于癌症的作用主要并不是直接刺激癌细胞增殖或者促进细胞生存(尽管这些方面并不容忽视),而是它与肿瘤微环境的联系。其最受关注的与MMPs、透明质酸和各类转运体的...
许多先前的研究也表明,CD147基因的表达在肿瘤的发展中起着至关重要的作用。为了解CD147能否作为口腔癌的治疗靶点,利用CRISPR/Cas9基因编辑技术敲除cal27细胞中的CD147基因,获得敲除细胞系。使用CCK-8、Transwell、RT-PCR和Western印迹,敲除细胞系的增殖和侵袭能力显着降低,基质金属蛋白酶的表达也受到抑制。下一个,构建...
Results CD147 gene expression in the ACS group was significantly increased compared to the control group ( p < 0.001). The ACS was 9.71 卤 3.56-fold; the control group was 0.94 卤 0.19-fold. Also, the SOD activity in the ACS group was significantly increased when compared to the control...
Figure. Gene Sequencing (Extract) Figure. SDS-PAGE [ IMPORTANT NOTE ] The kit is designed for research use only, we will not be responsible for any issue if the kit was used in clinical diagnostic or any other procedures. 特别提示:本公司的所有产品仅可用于科研实验,严禁用于临床医疗及其他非科...
货号:HZ505420TP用途范围:Positive Control; Immunogen; SDS-PAGE; WB 规格:10ug 50ug 100ug 200ug 1mg Eukaryotic Cluster Of Differentiation 147 (CD147) Sequence Information Species:Human Gene ID:682 Swiss Prot:P35613 Synonyms:EMMPRIN; BSG; 5F7; M6; OK;TCSF; Basigin(Ok Blood Group);Collagenase...
1) CD147 gene CD147基因1. Objective To construct the siRNA eukaryotic expression plasmids targeting human CD147 gene and observe their effects on CD147 gene expression in HeLa cells. 目的构建针对人CD147基因的siRNA真核表达质粒,并观察其对HeLa细胞中CD147基因表达的影响。
Keywords: 三阴性乳腺癌,CD147,基因沉默,增殖,迁移,triple negative breast cancer,CD147,gene silence,proliferation,migration Full-Text Cite this paper Add to My Lib Abstract: 目的·探讨CD147基因沉默对三阴性乳腺癌细胞的增殖抑制作用及机制。方法 ·体外培养人正常乳腺上皮细胞HMEC及3株三阴性乳腺癌细胞株...
Inhibition of CD147 gene expression via RNA interference reduces tumor cell invasion, tumorigenicity and increases chemosensitivity to paclitaxel in HO-8910pm ... W.,Chen,H.,... - 《Journal of Oral Pathology & Medicine》 被引量: 171发表: 2008年 Inhibition of CD146 gene expression via RNA in...
[8] Yang J, Wang R, Li H, et al. Lentivirus mediated RNA interference of EMMPRIN (CD147) gene inhibits the proliferation, matrigel invasion and tumor formation of breast cancer cells [J]. Cancer Biomark, 2016, 17(2): 237-247.
Thetertiary structure prediction presented that CD147 contains two extracellularlike cbmains. The Oryctolagus cundculusCD147 gene has been submitted to GenBank(Accession EU650668).doi:10.7668/hbnxb.2009.01.021贾海丽韩立强杨国宇钟凯郭豫杰台玉磊刘涛李平王艳玲华北农学报...