Methods CD141DC were magnetically purified from synovial fluid mononuclear cells (SFMC) and peripheral blood mononuclear cells (PBMC) stimulated and stained with a panel of fluorochrome conjugated antibodies for multicolour flow cytometry. CD141 DC isolated and purified from IA synovial fluid were ...
蛋白别名: BDCA-3; CD141; CD141 antigen; DC141; Fetomodulin; sCD141; soluble CD141; Thrombomodulin; TM 基因别名: AHUS6; BDCA3; CD141; THBD; THPH12; THRM; TM UniProt ID: (Human) P07204 Entrez Gene ID: (Human) 7056 功能 receptor activity transmembrane signaling receptor activit...
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Human CD141+ dendritic cells (DCs), specialized for cross-presentation, have been extensively studied in the development of DC-based therapy against cancer. A series of attempts was made to generate CD141+ DCs from cord blood CD34+ hematopoietic progenitors to overcome the practical limitation of...
蛋白别名: BDCA-3; CD141; CD141 antigen; DC141; Fetomodulin; sCD141; soluble CD141; Thrombomodulin; TM 基因别名: AHUS6; BDCA3; CD141; THBD; THPH12; THRM; TM UniProt ID: (Human) P07204 Entrez Gene ID: (Human) 7056 功能 receptor activity transmembrane signaling receptor activit...
目的探讨RA患者外周血各DCs亚群数量的变化,为进一步阐明RA的发病机制奠定基础.方法选取63例RA患者和30例相匹配的健康体检者作为正常对照组,将入选的RA患者根据疾病活动性评分(DAS28)分为3个亚组.采用流式细胞术检测所有受试者外周血DCs,Treg细胞比例并分析各DC亚群与Treg的相关性.结果 RA患者外周血总的DCs数量低于...
Human skin immune homeostasis, and its regulation by specialized subsets of tissue-residing immune sentinels, is poorly understood. In this study, we identify an immunoregulatory tissue-resident dendritic cell (DC) in the dermis of human skin that is characterized by surface expression of CD141, CD...
High CCR7 expression level in human tumors correlates with signatures of CD141+DC and better clinical outcomes.doi:10.1016/j.ccell.2016.06.003Roberts, Edward?W.Broz, Miranda?L.Binnewies, MikhailHeadley, Mark?B.Nelson, Amanda?E.Wolf, Denise?M....
Pancreatic ductal adenocarcinoma (PDAC) has a poor 5-year overall survival rate. Patients with PDAC display limited benefits after undergoing chemotherapy or immunotherapy modalities. Herein, we reveal that chemotherapy upregulates placental growth factor (PlGF), which directly activates cancer-associated ...
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