在一些实施方案中,提供了本文所述的cd123抗体或cd123 adc在制备用于抑制表达cd123的恶性细胞转移的药物中的用途。在一些实施方案中,提供了本文所述的cd123抗体或cd123adc在制备用于诱导肿瘤退行的药物中的用途。 30、本文还提供了将抗体与aclysvalcitpabc-dmae-co_cpi-000638314(aclyspabc-cpi-8314)缀合的方法。
Han and coworkers reported the development of optimized ADC based on a novel DNA-damaging payload, cyclopropa[c]pyrrolo[3,3-e]indole-4 one dimer (CPI dimer), that is bound to an engineered Y296Q residue in the antibody heavy chain via transglutaminase mediated conjugation, enabling an ADC ...