Ex vivo and mouse studies suggest an engineered IL-2 superkine, called super-2, could be used as an immunotherapy to help treat cancer. Further details on the research, next steps and licensing status are discussed in the article.SciBX: Science-Business eXchangedoi:10.1038/scibx.2012.412None
(γc, CD132) alone or with the γc subunit and the IL-2Rα subunit (CD25) to generate intermediate or high affinity IL-2 receptor complexes, respectively. CD122 expression levels can be upregulated by activation. The 5H4 antibody does not block IL-2 binding to the IL-2 receptor. CD...
To determine whether the IL-2C administration induces apoptosis of PP B cells, we compared staining with Annexin-5 and 7-AAD on B cells in the PPs versus B cells in the spleen. The frequency of total apoptotic (Annexin+7AAD−) and dead (Annexin+7AAD+) B cells was similar in spleens...
ChemicalBook provide Chemical industry users with Biotin Anti-Mouse CD122/IL-2RB Antibody[5H4] Boiling point Melting point,Biotin Anti-Mouse CD122/IL-2RB Antibody[5H4] Density MSDS Formula Use,If You also need to Biotin Anti-Mouse CD122/IL-2RB Antibody[5
Il aurait suffit 音乐剧《摇滚红与黑》曲目 演唱:Côme,Haylen,Juliette Béhar Part 01. 创作背景 (Le Rouge et Le Noir) 法语音乐剧《摇滚红与黑》(Le rouge et le noir - L'Opéra Rock)改编自司汤达的长篇名著《红与黑》。 该剧是对《红与黑》...
מאמר זה מתאר עדכון 3213549 עבור Microsoft Office 2016 שפורסמו ב- 5 ביולי, 2017. עדכון זה כולל את תנאי מוקדם....
doi:10.1038/scibx.2012.412Science-Business eXchange - Ex vivo and mouse studies suggest an engineered IL-2 superkine, called super-2, could be used as an immunotherapy to help treat cancer.Nature Publishing Group USScience-Business eXchange
This ''specific'' pSTAT-5 expression detected in nTreg cells ex vivo was likely due to a very recent signal given by IL-2/IL-15 cytokines in vivo since (i) it disappeared rapidly if cells were left unstimulated in vitro and (ii) was also observed if total thymocytes were stimulated ...
1278 Targeting IL-15 signaling with an anti-CD122 antibody durably reverses vitiligodoi:10.1016/j.jid.2018.03.1294Jillian RichmondJames P. StrassnerLucio ZapataMadhuri GargJohn E. HarrisJournal of Investigative Dermatology
Rhoneil, PenaJha, PriyamCharych, Deborah HDoberstein, Stephen KHoch, UteBioMed CentralJournal for ImmunoTherapy of CancerMurali A, et al. Synergistic antitumor activity of the CD122-biased immunostimulatory cytokine NKTR-214 when combined with anti-PD-1 in murine tumor models. J Immunother Cancer...