The aim of this work was to validate the CD11c‐DTR+ mouse model proving that the observed effects are not due to the DT itself, using littermates negative for the transgene and therefore resistant to DC depletion by DT. Methods: CD11c‐DTR+ and CD11c‐DTR‐ mice (5 months, both sexes...
给CD11c-DTR小鼠腹腔注射DT(白喉毒素),可以完全清除肠道巨噬细胞和树突状细胞,而巨噬细胞和树突状细胞在肠道重新发育回来存在时间窗口期。DT注射后3天后树突状细胞优先发育回来,两周后巨噬细胞才能在肠道中发育回来。利用这种方法我们可以在体内研究巨噬细胞缺失对DSS(葡聚糖硫酸钠)诱导的急性结肠炎的发生发展产生怎样...
Diphtheria toxin depletes CD11c-DTR mice of CD11c+ cells.Frida HenningssonZhoujie DingJoakim S. DahlinMarius LinkeviciusFredrik CarlssonKjellOlov GrönvikJenny HallgrenBirgitta Heyman
Methods We utilized the B16-SIY melanoma model, CD11c-DTR-GFP, and CD11c-DTR-GFP/Batf3 KO bone marrow chimeras to study the role Batf3+ DCs play ... A Ziblat,B Horton,E Higgs,... - 《Journal for Immunotherapy of Cancer》 被引量: 0发表: 2021年 加载更多来源...
CD11c.DTRDendritic cellsDepletionDiphtheria toxin receptor (DTRMonocytesMonocytosisDendritic cells (DCs) play a vital role in innate and adaptive immunity. Inducible depletion of CD11c(+) DCs engineered to express a high affinity diphtheria toxin receptor has been a powerful tool to dissect DC ...
2005. Histological analysis of CD11c-DTR/GFP mice after in vivo depletion of dendritic cells. Clin. Exp. Immunol. 141 : 398–404Probst HC, Tschannen K, Odermatt B, Schwendener R, Zinkernagel RM, et al. Histological analysis of CD11c-DTR/GFP mice after in vivo depletion of dendritic cells...
Depletion of CD11c(+) cells in the CD11c.DTR model drives expansion of unique CD64(+) Ly6C(+) monocytes that are poised to release TNF-alpha... Sivakumaran,Shivajanani,Henderson,... 被引量: 0发表: 0年 Depletion of CD11c+cells in the CD11c.DTR model drives expansion of unique CD64+Ly...