骨髓来源的抑制性细胞(Myeloid-derived suppressor cells，MDSCs)是骨髓来源的一群异质性细胞，是树突状细胞(dendritic cells，DCs)、巨噬细胞和(或)粒细胞的前体，具有显著抑制免疫细胞应答的能力。小鼠MDSCs的表型为CD11b+Gr-1+，分两个亚型:粒细胞样的MDSCs(CD11b+Ly6C-Ly6G+)和单核细胞样的MDSCs...
骨髓来源的抑制性细胞(Myeloid-derived suppres洋战尼行sor cells,MDSCs)是骨髓来源的一群异质性细胞,是树突状细胞(dendritic cells,DCs)、巨噬细胞和(或)粒细胞的前体,具有显著抑制免富烈绍学治盾济条免疫细胞应答的能力。 小鼠MDSCs的表型为CD11b+Gr-1+,分两个亚型:粒细胞样的MDSCs(CD11b+Ly6C-Ly6G+)和...
M., Pencovich, N. CD11b + Ly6G + myeloid-derived suppressor cells promote liver regeneration in a murine model of major hepatectomy.doi:10.1096/fj.201801733RJohn Wiley & Sons, LtdThe FASEB Journal
CD11b(+)Ly6C(++)Ly6G(-) Cells with Suppressive Activity Towards T Cells Accumulate in Lungs of Influenza a Virus-Infected Mice. Almeida,T,etc.CD11b(+)Ly6C(++)Ly6G(-) Cells with Suppressive Activity Towards T Cells Accumulate in Lungs of Influenza a Virus-Infected Mice.[J]... P Milanez...
为进一步明确具体哪一类免疫细胞参与此过程,作者应用流式细胞技术分析了Ang II灌注的动脉中炎症细胞,结果表明CD45+CD11b+Ly6C+Ly6G-F4/80+巨噬细胞呈现时间依赖性地增加。这些结果提示,骨髓巨噬细胞中CD11b的表达上调可能参与高血压的发生发...
Ly6GlowG-MDSC对葡萄糖代谢限制更敏感 为了确定限糖对免疫细胞的影响,将荷瘤小鼠分离的脾脏免疫细胞分为三组,分别在无葡萄糖培养基或引入广泛使用的糖代谢抑制剂2DG培养基中体外培养(图6A1-A2)。结果表明,葡萄糖+/2DG-组总膜联蛋白...
CD11b.sup.+.sup.Ly6C.sup.++.sup.Ly6G.sup.-.sup. cells show distinct function in mice with chronic inflammation or tumor burden Stenstrom M, Liberg D, Ivars F, Leanderson T (2012) CD11b+Ly6C++Ly6G- cells show distinct function in mice with chronic inflammation or tumor burden... E Ka...
在进行细胞表面分子染色前,用CD16/CD32抗体孵育细胞悬液封闭细胞表面的Fc受体。用于检测细胞表面蛋白的抗体包括:购自ebioscience的CD3e、CD4、CD8a、CD19、NK1.1、F4/80、CD45、CD11b、CD45.1、CD45.2、Ki67、Ly6C和购自biolegend的CD115、Ly6G、和Siglec-F。IL4Rα抗体购自R&D。
Ly6g-phycoerythrin was then used to negatively gate out all neutrophils, and all lymphocytes were gated out based on their lower FSC-A and SSC-A profile. This allowed FACS analysis on the remaining MΦ/monocyte subpopulations. AMΦs were discriminated from dendritic cells based on their high ...
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