CD103+ MLN DCS PROMOTE TR-CELL DEVELOPMENT THROUGH A TGF- AND RETINOIC ACID-DEPENDENT MECHANISM A confounding issue in the further characterization of gut- derived migratory DCs has been the lack of markers to distin- guish these cells from the lymphoid tissue-resident DCs within the MLN. ...
We next examined whether migratory CD103− cells possessed the other defining property of DCs, the ability to present antigen to naive T cells. To do this, the three subsets of LDCs were sorted, pulsed with ovalbumin, and co-cultured with CFSE (carboxyfluorescein succinimi- dyl ester)-...
Migratory CD103+ DCs were the only cells able to promote OT-I T cell activation and proliferation (Figure 1I). Altogether, these results demonstrate the unique ability of tumor-infiltrating CD103+ DCs to transport and cross-present tumor-associated antigens to CD8+ T cells in the TdLN, ...
CD103(+)CD11b(+) dendritic cells (DCs) represent the major migratory DC population within the small intestinal lamina propria (SI-LP), but their in vivo function remains unclear. Here we demonstrate that intestinal CD103(+)CD11b(+) DC survival was dependent on interferon regulatory factor 4...
Our results suggest that CD103+ DCs are the major migratory DC population in the intestinal mucosa and play a central role in initiating immune responses to luminal antigen in draining MLNs. In contrast we find that CX3CR1+ cells resemble tissue macrophages, are non-migratory and inefficient ...
It is generally thought that migratory tumor DCs are required to prime a de novo T cell response within the draining lymph nodes (Chen and Mellman, 2013). These can be divided into two lineages in mice: the predominant CD11b+ cDC2 population depends on the transcription factor interferon ...
Migratory properties of pulmonary dendritic cells are determined by their developmental lineage The chemokine receptor, CCR7, directs the migration of dendritic cells (DCs) from peripheral tissue to draining lymph nodes (LNs). However, it is unknown w... H Nakano,JE Burgents,K Nakano,... - ...
However, loss of SIRPα signaling in mice leads to a selective reduction in the CD103+CD11b+ subset of DCs in the small intestine, colon, and among migratory DCs in the mesenteric lymph node. In parallel, these mice have reduced numbers of TH17 cells in steady-state intestinal mucosa, ...
Finally, this subset exhibited a migratory DC phenotype and could take up and present orally administered antigens. Collectively, the MLN CD11b− CD103+ PD-L1High DC subset probably takes up luminal antigens in the intestine, migrates to MLNs, and highly induces regulatory T cells through ...
CD103(+)CD11b(+) dendritic cells (DCs) represent the major migratory DC population within the small intestinal lamina propria (SI-LP), but their in vivo fu... EK Persson,H Uronen-Hansson,M Semmrich,... - 《Immunity》 被引量: 468发表: 2013年 Intestinal Dendritic Cells Specialize to Ac...