The 伪E integrin chain CD103 identifies a subset of migratory dendritic cells (DCs) in the gut, lung, and skin. To gain further understanding of the function of CD103(+) DCs in regulating adaptive immunity in vivo, we coupled ovalbumin (OVA) to the CD103 antibody M290 (M290.OVA). ...
Our analysis of lymph cells revealed the presence of a significant number of CD103− cells, which possess the phenotypic and migratory hallmarks of DCs. We next examined whether migratory CD103− cells possessed the other defining property of DCs, the ability to present antigen to naive T ce...
Therefore, migratory CD103 þ DC might bring gut luminal antigens to the mLNs for presentation to CD4 T cells, either directly or upon transfer to other DCs. Such presentation might result in generation of Th17 cells, but only inefficient iTreg induction, a dysbalance that may lead to ...
It is generally thought that migratory tumor DCs are required to prime a de novo T cell response within the draining lymph nodes (Chen and Mellman, 2013). These can be divided into two lineages in mice: the predominant CD11b+ cDC2 population depends on the transcription factor interferon ...
The 伪E integrin chain CD103 identifies a subset of migratory dendritic cells (DCs) in the gut, lung, and skin. To gain further understanding of the functi... M Semmrich,M Plantinga,M Svensson-Frej,... - 《Mucosal Immunology》 被引量: 92发表: 2011年 Mouse lung CD103+ and CD11bhigh...
The majority of these migratory DCs express the 伪 integrin chain CD103, and in this study we demonstrate that the steady-state mobilization of CD103(+) DCs into the MLN is in part governed by the IL-1R family/TLR signaling adaptor molecule MyD88. Similar to mice with complete MyD88 ...
Activation of TLR4 results in maturation and survival of dendritic cells (DCs) to activate T cells in the spleen. Interestingly, little is known how miR-146a regulates DC phenotype/function and whether it has direct effects on the regulation of effector T cell function. To probe this question,...
Complement Mediated Signaling on Pulmonary CD103+ Dendritic Cells Is Critical for Their Migratory Function in Response to Influenza Infectiondoi:10.1371/journal.ppat.1003115Trafficking of lung dendritic cells (DCs) to the draining lymph node (dLN) is a crucial step for the initiation of T cell ...
The DC migratory defect in the absence of Flightless-1 was supported by decreased CCR7 expression in both cDC1 and cDC2 populations. We hypothesize that the observed defects in phagocytosis and migration in Flightless-1-deficient dendritic cells are due to an altered actin cytoskeleton, which may ...
DISCUSSION CD103+ DCs are the major migratory DC population in the SI and have a central role in initiating immune responses to luminal antigen in draining MLN. Both SI-LP and MLN CD103+ DCs are imprinted with the ability to metabolize retinol, a property that underlies their enhanced ...