Background: Drug-reactive T cells are involved in most drug-induced hypersensitivity reactions. The frequency of such cells in peripheral blood of patients with drug allergy after remission is unclear. Objective: We determined the frequency of drug-reactive T cells in the peripheral blood of ...
Wang, Z. Q. et al. CD103 and intratumoral immune response in breast cancer. Clin. Cancer Res. 22, 6290–6297 (2016). Edwards, J. et al. CD103+ tumor- resident CD8+ T cells are associated with improved survival in immunotherapy- naive melanoma patients and expand significantly during ant...
共鉴定出16个细胞群,包括8个CD4细胞群和8个CD8细胞群。对这些群一一命名和按marker注释,不是重点这里就不展开了。 DP细胞由高IRScore细胞组成,而DN细胞中最少。CD8细胞的IRScore明显高于CD4细胞,因为CD8细胞中DP细胞的百分比更高。DP细胞显示出细胞毒性和耗竭标记基因表达,而DN细胞具有更高的幼稚基因表达,SP细胞则...
CD103 Is a Marker for Alloantigen-Induced Regulatory CD8+ T Cells The alphaEbeta7 integrin CD103 may direct lymphocytes to its ligand E-cadherin. CD103 is expressed on T cells in lung and gut and on allograft-infiltrating... E Uss,AT Rowshani,B Hooibrink,... - 《Journal of Immunology...
The histograms show the expression of the indicated marker on CD103− (green), CD103+ CD11b+ (red), and CD103+ CD8 + (blue) cells. The filled histogram represents the appropriate isotype control gated on total CD11c+ MHCIIhi cells. Results in (d) and (e) are representative of ...
对这些群一一命名和按marker注释,不是重点这里就不展开了。 DP细胞由高IRScore细胞组成,而DN细胞中最少。CD8细胞的IRScore明显高于CD4细胞,因为CD8细胞中DP细胞的百分比更高。DP细胞显示出细胞毒性和耗竭标记基因表达,而DN细胞具有更高的幼稚基因表达,SP细胞则处于中间状态。DP细胞与DN细胞的基因表达差异也可以看出...
Flow cytometry was performed using a FACSCalibur (BD bioscience), and data were analyzed using FlowJo (TreeStar, Inc., Ashland, OR, USA) software. The percentage of positive cells for a given marker was based on cutoff points chosen to exclude >99% of the negative control population. For ...
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T cells and dendritic cells (DCs) that are positive for the tissue-resident marker CD103 play a vital role in antitumor immunity. In this study, multiplexed immunohistochemistry was applied to stain CD103 and the T-cell marker CD8 as well as the DC marker CD11c on formalin-fixed, paraffin-...
In contrast, Foxp3, a marker of regulatory T cells, was expressed in DC aggregates on T-cell transfer, coinciding with the appearance of CD103+ CD25− T cells in these clusters. Foxp3 was enriched in the CD103+ T-cell fraction isolated from the lamina propria of diseased mice. T-...