CD61KOand WT CD61−T cell clones (from patient 1) following activation with antigenic cancer cells, by flow cytometry. ♦, WT CD61+T cell clone; •, WT CD61siRNA-treatedT cell clone, ♠, WT CD61KOT cell clone; ♣, WT CD61−T cell clone.b, Horizontal bar graph showing...
刘颂利用sting基因敲除小鼠证明,cd103+cdc内的sting能够识别细菌释放的c-di-gmp,进而介导肠粘膜th17应答,抑制treg分化。由此可见,cd103+dc在维持肠黏膜免疫与免疫耐受平衡中起着重要作用,建立一种cd103+dc稳定的体外培养方法,对研究cd103+dc起源、生物学特征、治疗应用具有重要意义。技术实现要素:本发明的目的就是...
Further studies will be needed to determine the individual impact of CD103 on their function in vivo for the control of development of psoriasiform dermatitis by creating Cd103flox/flox mice to analyze cDC- or CD8+ T cell-specific CD103-ablation in mice. In conclusion, we described that CD...
1. Introduction Dendritic cells (DCs) capture antigens (Ags) and migrate to draining lymph nodes (LNs) to activate T cells, connecting innate to adaptive immune responses. Generally, there are three main DC populations: group 1 conventional DC (cDC1), group 2 conventional DC (cDC2), and pl...
Therefore, while αTIM-3 enhances a CD8+ T cell-dependent response to chemotherapy, the data indicate that this occurs via an indirect mechanism of action, consistent with high TIM-3 expression (Figure 1B) and the functional importance (Figures 3A–3D) of the cDC1 subset. Download: Download...
The proportion of DP CD8+ TRM cells are positively correlated with the proportion of type 1 conventional DCs (cDC1s) The direct cytotoxic effect of CD8+ T cells on tumor cells relies on their ability to recognize tumor-associated antigens. Additionally, cross-presentation by specialized antigen ...
These data expand our current understanding of the mucosal immune responses promoted by sFliC and highlights the potential of this adjuvant for vaccine usage by taking advantage of the functionality of mucosal CD103+CD11b+ cDC2.doi:10.3389/FIMMU.2018.02409Adriana Flores-Langarica...
Combining anti-CTLA-4 with cDCV therapy increased cDCV efficacy against lung metastases. Conclusions: Intratumor cDCV generated a systemic immune response inhibiting the growth of both the treated and untreated tumors, with increased T-cells in the tumor and lymph nodes. Systemic cDCV was ...
首先,该坦克最前端采用将近60毫米厚、装甲倾角78度的楔型匀质钢装甲。虽然看起来这部分装甲太薄了,但是按照装甲厚度计算公式计算相当于120毫米匀质钢装甲。与M60坦克车体首上装甲大致相等,强于AMX13和“豹”1的车首上装甲,还没有炮塔,减少了投影面积。
6月25日下午,自治区人民医院克拉玛依医院(市中心医院)隆重举行庆祝建党103周年暨“两优一先”表彰大会。院党委副书记、执行院长彭溢主持会议,党委副书记、纪委书记黄仁珍作党建工作报告,党委书记凌立省作重要讲话。院领导、受表彰的先进集体...