analysed using multicolor FACS analyses, cytokine and qPCR array in high sucrose diet (HSD) and methionine and choline deficient diet (MCD) fed wild-type and basic leucine zipper transcription factor, ATF-Like-3 (Batf3) deficient animals, which lack CD103+ DCs (classical type-1 DC, cDC1s)...
We reasoned that this inflammation may reflect a role for the mononuclear phagocytes that contribute to the generation and/or differentiation of pathogenic T cells in the intestine and thus we explored the populations of DCs and macrophages present in the mucosa ofRag1−/−Cre+mice. As has ...
cDC。虽然有从骨髓中诱导分化和培养CD103 + DC的成功案例,但要在体外获得数量足够的高纯度CD103 + DC,难度较大。 吞噬功能是树突状细胞抗原提呈生理机能得以启动的重要机制之一,未成熟的树突状细胞抗原吞噬作用强,抗原提呈功能弱;一旦树突状细胞成熟后,其吞噬作用减弱,抗原提呈作用增强,并高表达主要组织相容性复合...
Therefore, while αTIM-3 enhances a CD8+ T cell-dependent response to chemotherapy, the data indicate that this occurs via an indirect mechanism of action, consistent with high TIM-3 expression (Figure 1B) and the functional importance (Figures 3A–3D) of the cDC1 subset. Download: Download...
Abstract 4212: In situvaccination with Flt3l gene-modified CD103+type 1 conventional dendritic cells (cDC1) in murine models of non-small cell lung cancer ... A major hurdle in treatment of Non-Small Cell Lung Cancer (NSCLC) with anti-PD-1 immune checkpoint blockade (ICB) therapy is a ...
These results suggest that oral CD103−CD11b+ cDCs transport sublingual antigens to draining ManLNs and induce antigen-specific Foxp3+ Treg cells, and, thus, provide a rationale for developing cDC-based therapeutic approaches in SLIT. This is a preview of subscription content, access via your...
Anti-HAS1/Hyaluronan synthase 1/RBITC 罗丹明(RBITC)标记的透明质酸合成酶1抗体 Anti-CDC34B/UBC3B/RBITC 罗丹明(RBITC)标记的泛素载体蛋白R2抗体 Anti-CD9/MRP-1/RBITC 罗丹明(RBITC)标记的CD9蛋白抗体 Anti-CENPT/PE PE标记的着丝粒蛋白T抗体 ...
These data expand our current understanding of the mucosal immune responses promoted by sFliC and highlights the potential of this adjuvant for vaccine usage by taking advantage of the functionality of mucosal CD103+CD11b+ cDC2.doi:10.3389/FIMMU.2018.02409Adriana Flores-Langarica...
Combining anti-CTLA-4 with cDCV therapy increased cDCV efficacy against lung metastases. Conclusions: Intratumor cDCV generated a systemic immune response inhibiting the growth of both the treated and untreated tumors, with increased T-cells in the tumor and lymph nodes. Systemic cDCV was ...
DARA induces killing of tumor cells, mainly via complement-dependent cytotoxicity (CDC), antibody-dependent cell-mediated cytotoxicity (ADCC) (de We... A Matascéspedes,A Vidalcrespo,V Rodriguez,... 被引量: 5发表: 2014年 Hypogammaglobulinemia In Patients With Previously Untreated Chronic ...