刘颂利用sting基因敲除小鼠证明,cd103+cdc内的sting能够识别细菌释放的c-di-gmp,进而介导肠粘膜th17应答,抑制treg分化。由此可见,cd103+dc在维持肠黏膜免疫与免疫耐受平衡中起着重要作用,建立一种cd103+dc稳定的体外培养方法,对研究cd103+dc起源、生物学特征、治疗应用具有重要意义。技术实现要素:本发明的目的就是...
We reasoned that this inflammation may reflect a role for the mononuclear phagocytes that contribute to the generation and/or differentiation of pathogenic T cells in the intestine and thus we explored the populations of DCs and macrophages present in the mucosa ofRag1−/−Cre+mice. As has ...
Further studies will be needed to determine the individual impact of CD103 on their function in vivo for the control of development of psoriasiform dermatitis by creating Cd103flox/flox mice to analyze cDC- or CD8+ T cell-specific CD103-ablation in mice. In conclusion, we described that CD...
Therefore, while αTIM-3 enhances a CD8+ T cell-dependent response to chemotherapy, the data indicate that this occurs via an indirect mechanism of action, consistent with high TIM-3 expression (Figure 1B) and the functional importance (Figures 3A–3D) of the cDC1 subset. Download: Download...
The proportion of DP CD8+ TRM cells are positively correlated with the proportion of type 1 conventional DCs (cDC1s) The direct cytotoxic effect of CD8+ T cells on tumor cells relies on their ability to recognize tumor-associated antigens. Additionally, cross-presentation by specialized antigen ...
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Influenza virus remains a significant public health threat and is responsible for 200,000 hospitalizations and 3,000–49,000 deaths each year in the United States (Centers for Disease Control and Prevention (CDC), 2010, Thompson et al., 2003). While annual influenza vaccines are capable of pro...
These data expand our current understanding of the mucosal immune responses promoted by sFliC and highlights the potential of this adjuvant for vaccine usage by taking advantage of the functionality of mucosal CD103+CD11b+ cDC2.doi:10.3389/FIMMU.2018.02409Adriana Flores-Langarica...
Combining anti-CTLA-4 with cDCV therapy increased cDCV efficacy against lung metastases. Conclusions: Intratumor cDCV generated a systemic immune response inhibiting the growth of both the treated and untreated tumors, with increased T-cells in the tumor and lymph nodes. Systemic cDCV was ...
2024年7月1日,为庆祝中国共产党成立103周年,北方巴特莱党支部召开党员大会。大会开始前,全体党员齐唱国歌,在庄严的旋律中感受到中国共产党的伟大。 公司董事长毛永慧传达北方车辆集团党委庆祝中国共产党成立103周年大会会议内容,向支部党员传达学习了兵...