The examination of CCR2 signaling in the context of TBI has provided important information about general myeloid cell biology. Both Hsieh et al. [37] and Morganti et al. [68] studied gene expression in specific cell populations after TBI by qPCR and microarray analysis, respectively. Hsieh et...
目的探讨CC类趋化因子受体2 ( C-C motif chemokine receptor 2,CCR2)对肺气肿小鼠模型中单核细胞型髓源性抑制性细胞(monocytic myeloid-derived suppressor cells,M-MDSC)向肺脏迁移的影响。 方法将10只雄性野生型(wild type,WT)C57BL/6小鼠随机分为正常对照组和肺气肿模型组,每组5只。分别应用H&E染色和马松(...
Myeloid Lineage Markers Myeloid-derived Suppressor Cells (MDSC) Obesity Platelet Cytokine and Growth Factor Receptors Receptors in the Jak/STAT Pathway Regulatory T Cells (Tregs) T Cell Migration/Adhesion Uptake of Amyloid beta by Macrophages
Further- more, our results showing that CCR2 dependence is not a reliable indicator of monocytic origin and that DCs and mfs are truly derived from distinct precursors raise important issues that need to be considered in the clinical situations where monocyte-derived cells and myeloid cell growth ...
Furthermore, our results showing that CCR2 dependence is not a reliable indicator of monocytic origin and that DCs and mφs are truly derived from distinct precursors raise important issues that need to be considered in the clinical situations where monocyte-derived cells and myeloid cell growth ...
Selective chemokine receptor usage by central nervous system myeloid cells in CCR2-red fluorescent protein knock-in mice. PLoS One. 2010;5(10), e13693. Article PubMed Central PubMed Google Scholar Ajami B, Bennett JL, Krieger C, McNagny KM, Rossi FMV. Infiltrating monocytes trigger EAE ...
(CD11b+Ly6G+) and CD11c+cells exhibited apparent accumulation on the fifth day in this model, which corresponded to the colitis becoming serious on the fifth day (Fig.6F). Interestingly, the myeloid-derived cells (CD11b+) and monocytes (CD11b+CCR2+) exhibited obvious elevation on the third...
so as to find out new therapeutic targets and as soon as to get rid of such dreadful disease. CCL2–CCR2 pathway helps the cancerous cell to progress and metastasize fully. In this chapter, we will focus on this particular axis and its relation to various cancers and how this axis is ...
Interestingly, the myeloid-derived cells Scientific Reports | 7: 5107 | DOI:10.1038/s41598-017-05255-7 6 www.nature.com/scientificreports/ Figure 5. The neutralizing antibody of PSMP mollified DSS-induced colitis via its effects on the monocytes/ macrophages and IL-6, TNF-α, CCL2, ...
Exemplary CSF1R-positive, CCR2-positive cell include, but are not limited to, tumor-associated macrophages (TAMs) and myeloid derived suppressor cells (MDSCs). Exemplary CSF1R-positive, CCR2-negative cells include, but are not limited to, tissue-resident macrophages (e.g., Kupffer cells), ...