macrophages18,19,20. During a M0-M1 macrophage polarization procession, our data showed that CCL2 expression was up-regulated but PSMP kept at low level. Because we found that the up-regulated expression of PSMP in DSS-induced mouse colitis was earlier than CCL2, we hypothesized that PSMP wa...
Finally, usingin vivo ovarian cancer models, compared with control or monotherapy, the combination of BETi (ABBV-075) and bevacizumab resulted in greater inhibition of tumor growth and macrophage infiltration ( p <0.05) and longer survival of tumor-bearing mice ( p <0.001).Our findings indicate...
Protective and pathogenic functions of macrophage subsets. Nat Rev Immunol. 2011;11:723–37. Article CAS PubMed PubMed Central Google Scholar Jaguin M, Houlbert N, Fardel O, Lecureur V. Polarization profiles of human M-CSF-generated macrophages and comparison of M1-markers in classically ...
Early pressure-overload hypertrophy is marked by circulating Ly6ChiCCR2+ monocytosis and augmented CCR2+ cardiac macrophage infiltration In our recent study (9), we found that circulating Ly6Chi monocytes, cardiac macrophages (primarily “M1” type), and dendritic cells expand early after TAC (at...
42,48,49 Our data also demonstrate that downregulating CCR2 expression in macrophages by RVG9R3LC-delivered siRNA contributes to this effect by reducing M1 macrophage levels in the AT. RVG9R3LC:siCCR2 treatment improves glucose tolerance and restores insulin sensitivity To test the effects of ...
OBJECTIVE: Adipose tissue inflammation induced by macrophage infiltration through the C-C motif chemokine receptor (CCR) 2 or CCR5 pathway has a pivotal role in obesity-related disease and insulin resistance. Here, the effect of PF4178903, a dual CCR2/CCR5 antagonist, on obesity and insulin resi...
‘M2 macrophage’ was coined to describe the different functional states of macrophages [76]. M1 or ‘classically activated’ macrophages are tumoricidal. They are activated by IFNγ or lipopolysaccharide, and characterized by high expression of IL-12 (Interleukin-12) and low expression of IL-10 ...
2023年3月22日,天津中医药大学现代中医药国家重点实验室Guanwei Fan团队在《Advanced Science》上发表题为“M2 Macrophage-DerivedsEVRegulate Pro-Inflammatory CCR2+ Macrophage Subpopulations to Favor Post-AMI Cardiac Repair”的文章,他们表明M2巨噬细胞来源的细胞外囊泡(sEV)通过mir -181b-5p依赖机制调节CCR2+...
The polarized M1 and M2 macrophages were distinguished from inactive M0 macrophage with the biomarker HLA-DR and CD209, respectively. b Flow cytometry analysis shows discrepant expression of PD-L1 and PD-L2 between HLA-DR+CD209− M1 macrophages and HLA-DR−CD209+ M2 macrophages. Data is ...
2a). Potentially indicating that as a result of age, there is a maladaptive response to injury related to the restraint of macrophage activation, similar to what is observed in humans [16]. Interestingly, we show that the anti-inflammatory [17] chemokine CX3CL1 is significantly downregulated ...