Ccr2-DTR mice treated with DT were much more susceptible to VACVΔC7L infection compared with WT mice treated with DT, with more rapid weight loss and 100% mortality at day 7 or 8 post infection (Fig. 5c, d). Depletion of CCR2+ mono- cytes also resulted in viremia and systemic ...
将IRES-DTRGFP插入到小鼠Ccr2基因终止密码子。 应用领域:DTR工具鼠;荧光示踪小鼠 *使用本品系发表的文献需注明: Ccr2-IRES-DTRGFP mice (Cat. NO. NM-KI-210102) were purchased from Shanghai Model Organisms Center, Inc.. 验证数据 图1.流式检测Ccr2-IRES-DTRGFP小鼠中GFP的表达情况。结果显示杂合子小...
TAMs are selectively depleted in advanced PTCs of Tg-Braf/Ccr2-DTR mice after treatment with DT.Mabel RyderMatti GildTobias M. HohlEric PamerJeff KnaufRonald GhosseinJohanna A. JoyceJames A. Fagin
CCR2WT mice, where monocytes were unaffected after DT treatment, cleared the pathogen from the intestine, and none of the animals succumbed to infection (Fig. 1c,d). In contrast, CCR2DTR mice where monocytes were depleted displayed impaired eradication of C. rodentium on days 14 and 16, ...
(D) Quantification of DTR+CD206+ BAMs in different border compartments after repopulation. Data are presented as mean ± SEM (n = 3 mice). (G–I) Two-photon chronic imaging of the infiltration and transformation of CCR2+ monocytes into BAM-like cells during repopulation. Arrowheads indicate ...
Fig 2C-F:因此作者对B6 CCR2-DTR donor mice给予了diphtheria toxin (DT)清除了小鼠CCR2+单核和巨噬细胞,并将心脏移植给syngeneic LysM-GFP recipients。双光子结果显示清除了CCR2+单核和巨噬细胞之后,中性粒细胞的渗出显著减少。同样的,中性粒的rolling没有受影响,但是crawl显著下降了。
将IRES-DTRGFP插入到小鼠Ccr2基因终止密码子。 应用领域:DTR工具鼠;荧光示踪小鼠 *使用本品系发表的文献需注明: Ccr2-IRES-DTRGFP mice (Cat. NO. NM-KI-210102) were purchased from Shanghai Model Organisms Center, Inc.. 验证数据 图1.流式检测Ccr2-IRES-DTRGFP小鼠中GFP的表达情况。结果显示杂合子...
after meningitis in CX3CR1-DTR transgenic mice did not protect mice from any of the systemic or hearing sequelae of pneumococcal meningitis.ConclusionsPneumococcal meningitis can have devastating effects on cochlear structure and function, although not all mice experienced hearing loss or cochlear damage...
将IRES-DTRGFP插入到小鼠Ccr2基因终止密码子。 应用领域:DTR工具鼠;荧光示踪小鼠 *使用本品系发表的文献需注明: Ccr2-IRES-DTRGFP mice (Cat. NO. NM-KI-210102) were purchased from Shanghai Model Organisms Center, Inc.. 验证数据 图1.流式检测Ccr2-IRES-DTRGFP小鼠中GFP的表达情况。结果显示杂合子...
将IRES-DTRGFP插入到小鼠Ccr2基因终止密码子。 应用领域:DTR工具鼠;荧光示踪小鼠 *使用本品系发表的文献需注明: Ccr2-IRES-DTRGFP mice (Cat. NO. NM-KI-210102) were purchased from Shanghai Model Organisms Center, Inc.. 验证数据 图1.流式检测Ccr2-IRES-DTRGFP小鼠中GFP的表达情况。结果显示杂合...