组织驻留巨噬细胞(Tissue-resident macrophages,TRMs)是一类特殊的巨噬细胞,它们在不同组织中具有独特的发育、驻留和维持机制。这些细胞通常来源于胚胎发生过程中的造血祖细胞,并且在特定的组织微环境中成熟和分化。TRMs具有组织特异性,它们能够长期驻留在特定的组织部位,执行一系列重要的生理功能,如组织稳态维持、免疫防御...
我们的研究结果表明,溶菌酶1可能是诊断肥胖引起的炎症和治疗肥胖引起的心脏病的潜在靶点。 Lysozyme 1 Inflamed CCR2Macrophages Promote Obesity-Induced Cardiac Dysfunction Circulation Researcharticle Early Recent, July 26, 2024 10.1161/CIR...
2024年7月26日,南京医科大学陈琪/张瀚文团队在Circulation Research杂志上发表题为“Lysozyme 1 Inflamed CCR2+Macrophages Promote Obesity-Induced Cardiac Dysfunction”的研究论文,首次揭示溶菌酶1介导CCR2+巨噬细胞增炎性功能转变促进肥...
本期介绍的时空/细胞组学相关研究文章共计2篇。以下是应用时空云平台STOmics Cloud的StereoCopilot模块生成的文章概要,并辅以人工审核,供了解参考。 1、溶菌酶1激活的CCR2+巨噬细胞促进肥胖引起的心脏功能障碍 Lysozyme 1 Inflamed CCR2+ Macrophages Promote Obesity-Induced Cardiac Dysfunction Circulation Research; ...
Finally, RNA in situ hybridization (Figure B-C) demonstrated increased levels of Cxcl9 (red) expression in cells consistent with CCR2\n+\n(white) macrophages when comparing isotype control to treatment with CD40ag. These findings reveal that CD40 activation results in a robust expansion of CC...
CCL2, also known as MCP-1, is a potentchemokinefor the recruitment process of macrophages,monocytes, activatedT cellsandNK cellsto the CNS[47]. MCP is an important member of the CC subfamily. To date, five MCPs are identified and classified: from MCP-1to MCP-5, which means CCL2,CCL8...
Following acute myocardial ischemia reperfusion (MIR), macrophages infiltrate damaged cardiac tissue and alter their polarization phenotype to respond to acute inflammation and chronic fibrotic remodeling. In this study we investigated the role of macrophages in post-ischemic myocardial fibrosis and explored...
The chemokine receptor, CCR2, is predominantly expressed on monocytes/macrophages, and on a subset of memory T cells. It binds to several CC type chemokines of the monocyte chemoattractant protein (MCP) family of which MCP-1 exhibits the highest affinity. CCR2/MCP-1 expression/association in ...
However, the specific role of innate immune cells, especially CCR2 macrophages on the outcome of cardiomyocyte transplantation, is unclear. Methods We compared the cellular, molecular, and functional outcome following cardiomyocyte transplantation in wildtype and T cell- and B cell-deficient Rag2del ...
Doxycycline treatment impeded monocyte recruitment, inhibited polarization of alternatively activated macrophages, and suppressed T cell adaptive immune responses following infection. Our results determine a mechanism of action for the antimorbidity effects of doxycycline in filariasis and support clinical ...