P.160: Single-cell transcriptomics reveals that Ccl6/Ccr2 pathway induce migration and M2 polarization among macrophages in acute kidney injury.doi:10.1097/01.tp.0001067484.85717.f7Wang, JiayuZheng, XinHu, XiaopengChen, LiangLippincott Williams & WilkinsTransplantation...
CCR2 defines in vivo development and homing of IL-23-driven GM-CSF-producing Th17 cells.###The chemokine CCL20 induces proinflammatory and matrix degradative responses in cartilage.###Association of variants in CCR6 with susceptibility to lupus nephritis in Chinese.###Brief report: enrichment of ...
在慢性应激状态下,CCL2-CCR2轴可诱导巨噬细胞向促炎型(M1型)或抗炎型(M2型)极化。M1型巨噬细胞具有抗肿瘤作用,而M2型巨噬细胞则可能促进肿瘤生长和转移。 三、慢性应激对巨噬细胞极化的影响 慢性应激可导致机体免疫系统失衡,促使巨噬细胞向M2型极化。研究显示,慢性应激可通过增加CCL2的分泌,进一步激活CCR2受体...
CCL2 is a small cell-signaling protein that recruits immune cells to sites of inflammation. CCR2 is CCL2's receptor. Together, CCL2 and CCR2 create an inflammatory and immune-suppressive microenvironment, which promotes tumor growth and progression and induces resistance to anticancer drugs. A re...
成果类型: 项目 项目作者:范洪桥 项目作者单位: 湖南中医药大学第一附属医院 项目批准号: 2022JJ40331 立项时间: 2022 项目级别: 省部级 机构署名: 本校为第一完成单位 反馈 产权有误:本人成果被他人认领 数据有误:数据基本信息有误 归属有误:成果的院系归属、机构署名归属有误 其他原因: 验证码:...
Results indicated that physiological deficiency of IL-6 promoted the development of colitis. Moreover, IL-6 deficiency significantly increased the mRNA levels of monocytes chemokine Ccl2 and its receptor Ccr2 in colon tissues. Similarly, the percentage of Ly6Chighmonocytes and neutrophils were ...
PPD and ManLAM specifically down-regulated CCR2 expression but not that of CCR5 and CCR7, and such down-regulation was observed on all APC populations. Mtb Ag did not affect the expression of costimulatory molecules. PPD but not ManLAM specifically induced MCP-1/CCL2 production, which was ...