P.160: Single-cell transcriptomics reveals that Ccl6/Ccr2 pathway induce migration and M2 polarization among macrophages in acute kidney injury.doi:10.1097/01.tp.0001067484.85717.f7Wang, JiayuZheng, XinHu, XiaopengChen, LiangLippincott Williams & WilkinsTransplantation...
停止CCL2抑制治疗,会增加转移的形成,并导致患者过早死亡,从而消弱了治疗的最初有利影响。因此研究提示灭活趋化因子CCL2的治疗方法应格外小心使用。 C–C趋化因子配体2分泌(CCL2)的乳腺肿瘤的新兵CCR2表达的炎症单核细胞对原发性肿瘤和转移灶,并在小鼠中和抑制CCL2 metastasis1保留在骨髓单核细胞。CCL2在转移性乳腺...
CCL2主要通过其同源受体CCR2发挥作用:敲除Ccr2或通过药理学手段阻断CCR2的功能均可有效阻断CCL2对于GluA1的调控作用。其次,电生理实验结果显示CCL2孵育显著增加海马神经元的微小兴奋性突触后电流(miniature excitatory post-synaptic currents...
Targeting tumour-associated macrophages with CCR2 inhibition in combination with FOLFIRINOX in patients with borderline resectable and locally advanced pancreatic cancer: a single-Centre, open-label, dose-finding, non-randomised, phase 1b trial. Lancet Oncol. 2016;17:651–62. Article CAS PubMed Pub...
山东人学颁士学位论文 CCL20/CCR6系统在Th l7细胞介导的椎问盘源性腰腿痛中的作 用机制研究 硕士研究生:张稳 导师:聂林教授 专业:外科学(骨外科) 中文摘要 目的 腰椎间盘突出症(1umbar disc herniation,LDH)是临床常见病和多发病, 据目前的统计资料表明,腰椎问盘突出症患者约占因腰腿痛就诊患者的15%,美 ...
在慢性应激状态下,CCL2-CCR2轴可诱导巨噬细胞向促炎型(M1型)或抗炎型(M2型)极化。M1型巨噬细胞具有抗肿瘤作用,而M2型巨噬细胞则可能促进肿瘤生长和转移。 三、慢性应激对巨噬细胞极化的影响 慢性应激可导致机体免疫系统失衡,促使巨噬细胞向M2型极化。研究显示,慢性应激可通过增加CCL2的分泌,进一步激活CCR2受体...
and the CCL2/CCR2 axis has been shown to have multiple pro-tumor effects, ranging from mediating tumor growth and angiogenesis to recruiting and usurping host stromal cells to support tumor progression [46]. In a phase 1 trial, the administration of a CCR2 inhibitor (PF-04136309) was well...
2) To examine of the effects of IL-6 stimulation on monocyte chemokine receptor gene expression (CCR1, CCR2 and ... Ravi,A Kumar 被引量: 0发表: 2016年 Optimized Dialysis and Protease Inhibition of Sputum Dithiothreitol Supernatants Dithiothreitol (DTT) is commonly used to liquefy induced ...
Cell populations were gated into regions R1, R2, and R3 based on FSC/SSC parameters. CD14+ cells are shown in the lower right quadrants, CD206+ cells are shown in the upper left quadrants, and CD14+/CD206+ double-positive cells are shown in the upper right quadrants. The data displayed...