CCL21-CCR7 pathway has been implicated in the pathophysiology of numerous diseases, including lymph node metastases [43,44] and malignant brain tumors [45]. Moreover, ectopic and imbalanced expression of CCL21 has been observed in various contexts, including infectious [46,47], autoimmune [48],...
CCL21-CCR7 mediates microglial cell activation and neuroinflammation in mice. Navarixin inhibits the activation of CCR7 by CCL21 in microglial cells, thereby inducing neuroprotection both in vitro and in vivo and preventing PD-like behavioral deficits in mice....
ＣＸＣＬ１２－ＣＸＣＲ４轴、ＣＣＬ２１－ＣＣＲ７轴在非霍奇金淋巴瘤中的研究进展 卢莹莹，李文辉 ＲｅｓｅａｒｃｈａｄｖａｎｃｅｓｏｆＣＸＣＬ１２－ＣＸＣＲ４ａｘｉｓａｎｄＣＣＬ２１－ＣＣＲ７ａｘｉｓｉｎｎｏｎ－Ｈｏｄｇｋｉｎ＇ｓｌｙｍｐｈｏｍａ ＬＵＹｉｎｇｙｉｎｇ，ＬＩＷｅｎｈｕｉ Ｄｅｐａｒｔ...
CCL21的剂量依赖趋化性可能决定了肿瘤转移的方向和部位。CCL21一CCR7生物学 山东大学博士学位论文 轴在肿瘤淋巴归巢、血管生成及神经浸润方面有一定的作用。并且可以调控其它 趋化因子的分泌。 我们采用肝门高位切除并肝门实质一空肠吻合术做到扩大手术切除范围,尽 ...
趋化因子 ; CCL21 ; CCR7 ; 肿瘤转移 ; 靶点 [摘要] 趋化因子CCL21与其受体CCR7在肿瘤细胞选择性和特异性转移过程中发挥重要作用,可能成为抗肿瘤转移药物治疗的新靶点。就其结构和生物学功能、抗肿瘤作用机制、在恶性肿瘤转移中作用的研究进展作一综述,为抗肿瘤新药研发提供思路。 [Key word] Chemokine ; CCL21...
Intriguingly, although both CCR7 ligands, CCL19 and CCL21, are elevated in RA specimens, only CCL21 was predominately responsible for CCR7's pathological manifestation of RA. Unique subset of M肖s differentiated in response to CCL21 stimulation, exhibited upregulation in Th17-polarizing monokines....
目的:明确CCL21及其受体CCR7在类风湿关节炎(RA)发病机制中的作用。 方法:采用组织学研究比较RA滑膜组织中CCR7及CCL21表达差异。此外,通过体内及体外实评估CCL21和/或CCR7血管生成作用,体外实验检测其趋化作用及血管形成,体内实验选用基质凝胶塞试验。最后,通过Western blot法、内皮细胞趋化性及血管形成分析法评估CCL21...
Recently, CCL21-CCR7 signaling has emerged as a potential anti-tumor target. CCL21-CCR7 signaling activation has been associated with cancer cell invasion, metastasis and lymphangiogenesis in breast, prostate, head and neck and colon cancers, as well as B cell malignancies [33,34,35,36,37,38...
CCL21CCR7轴对肺腺癌A549(细胞增殖、迁移、侵袭及淋巴结转移的影响分析,CCL21CCR7轴对肺腺癌A549(细胞增殖、迁移、侵袭及淋巴结转移的影响分析,肺腺癌,肺..
CCL21／CCR7轴对人肺癌A549细胞VEGF—C表达影响的研究