在琼脂糖下测试 DC 或 T 细胞对 CCL19 的反应时,发现 T 细胞单独对均匀的 CCL19 反应很差(图 6A)。与 DC 混合后,一些 T 细胞通过短暂的、不依赖 CCR7 的相互作用与 DC 一起移动,但除此之外,一波 T 细胞以 CCR7/CCL19 依...
(2016). CCL19- CCR7-dependent reverse transendothelial migration of myeloid cells clears Chlamydia muridarum from the arterial intima. Nat Immunol. 17: 1263-1272.Roufaiel M, Gracey E, Siu A, Zhu S-N, Lau A, Ibrahim H, Althagafi M, Tai K, Hyduk SJ, Cybulsky KO, Ensan S, Li A, ...
摘要:目的研究趋化因子配体19(CCL19)及其受体趋化因子受体7(CCR7)在风湿性二尖瓣狭窄(RMS)患者瓣膜组织中的表达、分布特点和细胞定位。方法采用GeneChip Human Gene1.0ST基因芯片和免疫组织化学染色法检测RMS病变二尖瓣瓣膜(A组,16例)和正常瓣膜(B组,3例)中CCL19和CCR7的表达情况。结果 A组CCL19和CCR7均高表达;其中...
基本描述 产品名称 CCL19, ACKR4 激动剂;CCR7 激动剂;CCRL2 激动剂;CXCR3 激动剂 规格或纯度 Moligand™ 作用类型 激动剂 作用机制 ACKR4 激动剂;CCR7 激动剂;CCRL2 激动剂;CXCR3 激动剂 关联靶点(人) 产品规格参数 质检证书(CoA,COO,BSE/TSE 和分析图谱) 相关文档 溶液计算器...
显示CCL19,CCR7在RMS病变瓣膜组织中高表达,其中CCL19主要分布在炎症细胞区域,而CCR7主要在瓣膜间质细胞表达.在正常瓣膜组织中CCL19,CCR7均无表达.第二部分:免疫荧光染色证实R-MVICs(RMS MVICs,R-MVICs)表达CCR7,且CCL19因子不能显著上调其CCR7的表达,而N-MVICs(normal MVICs,N-MVICs)不表达CCR7,用CCL19因子...
Objective: Osteoarthritis (OA) is a non-rheumatologic joint disease characterized by progressive degeneration of the cartilage extra-cellular matrix (ECM), enhanced subchondral bone remodeling, activation of synovial macrophages and osteophyte growth. Inhibition of calcineurin (Cn) activity through tacrolimus...
摘要:肿瘤转移有其选择性和特异性,不同组织来源的肿瘤易向某些特定的组织和器官如淋巴结、肺、肝、骨等转移,但人们对其机制知之甚少。近年来,发现不少趋化因子及其受体在肿瘤的转移中扮演重要角色。现就CCL19/21-CCR7生物学轴在肿瘤转移中的作用作一综述。
CCR7 stimulation by CCL19 or CCL21 has recently been shown to result in MAP-kinase phosphorylation and this is likely to be involved in CLL cell survival [3]. CCL19 and CCL21, although activating the same receptor, are distinct in several features. For example, CCL21 is structurally prone...
In contrast, we found CCR7+CD8+ T cells infiltrated in the endomysium and CCL19 was expressed on muscle fibers as well as on infiltrated mononuclear cells in muscles of polymyositis. We also analyzed inclusion body myositis, but only in a small number of cases. In the present study, we ...
The CCR7 ligand elc (CCL19) is transcytosed in high endothelial venules and mediates T cell recruitment. J. Exp. Med. 2001; 193: 1105-1112Baekkevold ES, Yamanaka T, Palframan RT, Carlsen HS, Reinholt FP, von Andrian UH, Brandtzaeg P, Haraldsen G. The CCR7 ligand elc (CCL19) is...